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Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi

Systematic measurement of genetic interactions by combinatorial RNAi (co-RNAi) is a powerful tool for mapping functional modules and discovering components. It also provides insights into the role of epistasis on the way from genotype to phenotype. The interpretation of co-RNAi data requires computa...

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Hauptverfasser: Axelsson-Ekker, Elin (Verfasst von) , Sandmann, Thomas (Verfasst von) , Horn, Thomas (Verfasst von) , Boutros, Michael (Verfasst von) , Huber, Wolfgang (Verfasst von) , Fischer, Bernd (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 August 2011
In: BMC bioinformatics
Year: 2011, Jahrgang: 12, Pages: 1-10
ISSN:1471-2105
DOI:10.1186/1471-2105-12-342
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2105-12-342
Volltext
Verfasserangaben:Elin Axelsson, Thomas Sandmann, Thomas Horn, Michael Boutros, Wolfgang Huber and Bernd Fischer
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Zusammenfassung:Systematic measurement of genetic interactions by combinatorial RNAi (co-RNAi) is a powerful tool for mapping functional modules and discovering components. It also provides insights into the role of epistasis on the way from genotype to phenotype. The interpretation of co-RNAi data requires computational and statistical analysis in order to detect interactions reliably and sensitively.
Beschreibung:Gesehen am 25.03.2022
Beschreibung:Online Resource
ISSN:1471-2105
DOI:10.1186/1471-2105-12-342

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