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Pre-transplant serum leptin levels and relapse of acute myeloid leukemia after allogeneic transplantation

Weight loss and metabolic activity influence outcome after allogeneic stem cell transplantation (alloSCT). This study evaluates pre-conditioning Leptin, a peptide hormone involved in metabolism and immune homeostasis, as a prognostic factor for survival, relapse and non-relapse mortality (NRM) follo...

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Main Authors: Schwarzbich, Mark-Alexander (Author) , Dai, Hao (Author) , Kordelas, Lambros (Author) , Beelen, Dietrich W. (Author) , Radujković, Aleksandar (Author) , Müller-Tidow, Carsten (Author) , Dreger, Peter (Author) , Luft, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 20 February 2022
In: International journal of molecular sciences
Year: 2022, Volume: 23, Issue: 4, Pages: 1-13
ISSN:1422-0067
DOI:10.3390/ijms23042337
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms23042337
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/23/4/2337
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Author Notes:Mark-Alexander Schwarzbich, Hao Dai, Lambros Kordelas, Dietrich W. Beelen, Aleksandar Radujkovic, Carsten Müller-Tidow, Peter Dreger and Thomas Luft
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Summary:Weight loss and metabolic activity influence outcome after allogeneic stem cell transplantation (alloSCT). This study evaluates pre-conditioning Leptin, a peptide hormone involved in metabolism and immune homeostasis, as a prognostic factor for survival, relapse and non-relapse mortality (NRM) following alloSCT. Leptin serum levels prior to conditioning were determined in a cohort of patients transplanted for various hematologic malignancies (n = 524) and correlated retrospectively with clinical outcome. Findings related to patients with acute leukemia (AL) from this sample were validated in an independent cohort. Low pre-conditioning serum Leptin was an independent prognostic marker for increased risk of relapse (but not of NRM and overall mortality) following alloSCT for AL of intermediate and advanced stage (beyond first complete remission). Multivariate analysis revealed a hazard ratio (HR) for relapse of 0.75 per log2 increase (0.59-0.96, p = 0.020). This effect was similar in an independent validation cohort. Pre-conditioning serum Leptin was validated as a prognostic marker for early relapse by fitting the multivariate Cox model to the validation data. Pre-conditioning serum Leptin levels may serve as an independent prognostic marker for relapse following alloSCT in intermediate and advanced stage AL patients. Prospective studies are required to prove whether serum Leptin could be used for guiding nutritional intervention in patients with AL undergoing alloSCT.
Item Description:Gesehen am 06.04.2022
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms23042337

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