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Activation of AKT/mammalian target of rapamycin signaling in the peripheral blood of women with premature ovarian insufficiency and its correlation with FMR1 expression

The protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway regulates early follicular activation and follicular pool maintenance in female germline cells. Fragile X mental retardation 1 (FMR1) regulates folliculogenesis and it is variably expressed in patients with Premature O...

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Main Authors: Rehnitz, Julia (Author) , Messmer, Birgitta (Author) , Bender, Ulrike (Author) , Nguyen, Xuan Phuoc (Author) , Germeyer, Ariane (Author) , Hinderhofer, Katrin (Author) , Strowitzki, Thomas (Author) , Capp, Edison (Author)
Format: Article (Journal)
Language:English
Published: 05 March 2022
In: Reproductive biology and endocrinology
Year: 2022, Volume: 20, Pages: 1-7
ISSN:1477-7827
DOI:10.1186/s12958-022-00919-0
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12958-022-00919-0
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Author Notes:Julia Rehnitz, Birgitta Messmer, Ulrike Bender, Xuan Phuoc Nguyen, Ariane Germeyer, Katrin Hinderhofer, Thomas Strowitzki and Edison Capp
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Summary:The protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway regulates early follicular activation and follicular pool maintenance in female germline cells. Fragile X mental retardation 1 (FMR1) regulates folliculogenesis and it is variably expressed in patients with Premature Ovary Insufficiency. FMR1 expression is supposed to be linked to AKT/mTOR signaling in an ovarian response dependent manner as demonstrated in recent in vitro and in vivo studies in the female germline in vitro and in vivo.
Item Description:Gesehen am 05.04.2022
Physical Description:Online Resource
ISSN:1477-7827
DOI:10.1186/s12958-022-00919-0

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