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Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function

Amphotericin B is frequently used for the treatment of fungal infections of immunocompromised individuals. Whereas immunomodulatory side effects of this agent are known, the influence of amphotericin B was studied in the model of murine Listeria monocytogenes infection. Treatment of L. monocytogenes...

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Bibliographic Details
Main Authors: Geginat, Gernot (Author) , Kretschmar, Marianne (Author) , Walter, Simon (Author) , Junker, Dieter (Author) , Hof, Herbert (Author) , Nichterlein, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 8 September 1999
In: The journal of infectious diseases
Year: 1999, Volume: 180, Issue: 4, Pages: 1186-1194
ISSN:1537-6613
DOI:10.1086/315007
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1086/315007
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Author Notes:Gernot Geginat, Marianne Kretschmar, Simon Walter, Dieter Junker, Herbert Hof, Thomas Nichterlein
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Summary:Amphotericin B is frequently used for the treatment of fungal infections of immunocompromised individuals. Whereas immunomodulatory side effects of this agent are known, the influence of amphotericin B was studied in the model of murine Listeria monocytogenes infection. Treatment of L. monocytogenes-immune mice with a nontoxic dose of amphotericin B (0.75 mg/kg) reduced antilisterial protection by 4-5 orders of magnitude, while it had no significant effect on natural immunity against L. monocytogenes in naive mice. Treatment of mice with amphotericin B also abolished the protection mediated by transfer of an L. monocytogenes-specific CD8 T cell line. Furthermore, in vitro analysis showed that amphotericin B impaired target cell lysis and interferon-γ production by peptide-specific CD8 T cell lines and antigen presentation by L. monocytogenes-infected macrophagelike cells. These data indicate that amphotericin B has a strong suppressive effect on the function of CD8 T cells in vitro and in vivo.
Item Description:Gesehen am 06.04.2022
Physical Description:Online Resource
ISSN:1537-6613
DOI:10.1086/315007

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