Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function
Amphotericin B is frequently used for the treatment of fungal infections of immunocompromised individuals. Whereas immunomodulatory side effects of this agent are known, the influence of amphotericin B was studied in the model of murine Listeria monocytogenes infection. Treatment of L. monocytogenes...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
8 September 1999
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| In: |
The journal of infectious diseases
Year: 1999, Jahrgang: 180, Heft: 4, Pages: 1186-1194 |
| ISSN: | 1537-6613 |
| DOI: | 10.1086/315007 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1086/315007
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| Verfasserangaben: | Gernot Geginat, Marianne Kretschmar, Simon Walter, Dieter Junker, Herbert Hof, Thomas Nichterlein |
| Zusammenfassung: | Amphotericin B is frequently used for the treatment of fungal infections of immunocompromised individuals. Whereas immunomodulatory side effects of this agent are known, the influence of amphotericin B was studied in the model of murine Listeria monocytogenes infection. Treatment of L. monocytogenes-immune mice with a nontoxic dose of amphotericin B (0.75 mg/kg) reduced antilisterial protection by 4-5 orders of magnitude, while it had no significant effect on natural immunity against L. monocytogenes in naive mice. Treatment of mice with amphotericin B also abolished the protection mediated by transfer of an L. monocytogenes-specific CD8 T cell line. Furthermore, in vitro analysis showed that amphotericin B impaired target cell lysis and interferon-γ production by peptide-specific CD8 T cell lines and antigen presentation by L. monocytogenes-infected macrophagelike cells. These data indicate that amphotericin B has a strong suppressive effect on the function of CD8 T cells in vitro and in vivo. |
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| Beschreibung: | Gesehen am 06.04.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1537-6613 |
| DOI: | 10.1086/315007 |