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Pinealectomy affects bone mineral density and structure - an experimental study in sheep

Osteoporosis and associated fractures are a major public health burden and there is great need for a large animal model. Melatonin, the hormone of the pineal gland, has been shown to influence bone metabolism. This study aims to evaluate whether absence of melatonin due to pinealectomy affects the b...

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Bibliographic Details
Main Authors: Egermann, Marcus (Author) , Gerhardt, Christian (Author) , Barth, Alain (Author) , Maestroni, Georges J. (Author) , Schneider, Erich (Author) , Alini, Mauro (Author)
Format: Article (Journal)
Language:English
Published: 24 November 2011
In: BMC musculoskeletal disorders
Year: 2011, Volume: 12, Pages: 1-9
ISSN:1471-2474
DOI:10.1186/1471-2474-12-271
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2474-12-271
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Author Notes:Marcus Egermann, Christian Gerhardt, Alain Barth, Georges J. Maestroni, Erich Schneider and Mauro Alini
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Summary:Osteoporosis and associated fractures are a major public health burden and there is great need for a large animal model. Melatonin, the hormone of the pineal gland, has been shown to influence bone metabolism. This study aims to evaluate whether absence of melatonin due to pinealectomy affects the bone mass, structure and remodeling in an ovine animal model.
Item Description:Gesehen am 06.04.2022
Physical Description:Online Resource
ISSN:1471-2474
DOI:10.1186/1471-2474-12-271

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