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Pinealectomy affects bone mineral density and structure - an experimental study in sheep

Osteoporosis and associated fractures are a major public health burden and there is great need for a large animal model. Melatonin, the hormone of the pineal gland, has been shown to influence bone metabolism. This study aims to evaluate whether absence of melatonin due to pinealectomy affects the b...

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Hauptverfasser: Egermann, Marcus (VerfasserIn) , Gerhardt, Christian (VerfasserIn) , Barth, Alain (VerfasserIn) , Maestroni, Georges J. (VerfasserIn) , Schneider, Erich (VerfasserIn) , Alini, Mauro (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 24 November 2011
In: BMC musculoskeletal disorders
Year: 2011, Jahrgang: 12, Pages: 1-9
ISSN:1471-2474
DOI:10.1186/1471-2474-12-271
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2474-12-271
Volltext
Verfasserangaben:Marcus Egermann, Christian Gerhardt, Alain Barth, Georges J. Maestroni, Erich Schneider and Mauro Alini
Beschreibung
Zusammenfassung:Osteoporosis and associated fractures are a major public health burden and there is great need for a large animal model. Melatonin, the hormone of the pineal gland, has been shown to influence bone metabolism. This study aims to evaluate whether absence of melatonin due to pinealectomy affects the bone mass, structure and remodeling in an ovine animal model.
Beschreibung:Gesehen am 06.04.2022
Beschreibung:Online Resource
ISSN:1471-2474
DOI:10.1186/1471-2474-12-271

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