Increased soluble VCAM-1 serum levels in preeclampsia are not correlated to urinary excretion or circadian blood pressure rhythm
Objective : Soluble vascular cell adhesion molecule-1 (VCAM-1) is known to be elevated in serum of patients with preeclampsia, but there are no data available on the significance of urinary VCAM-1 excretion in preeclampsia. The aim of our study was to uncover possible circadian rhythms of VCAM-1 pla...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1. Juni 2005
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| In: |
Journal of perinatal medicine
Year: 2005, Volume: 33, Issue: 2, Pages: 144-148 |
| ISSN: | 1619-3997 |
| DOI: | 10.1515/JPM.2005.027 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1515/JPM.2005.027 Verlag, lizenzpflichtig, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/JPM.2005.027/html 
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| Author Notes: | W. Heyl, B. Heintz, F. Reister, S. Harwig, K. Witte, B. Lemmer and W. Rath |
| Summary: | Objective : Soluble vascular cell adhesion molecule-1 (VCAM-1) is known to be elevated in serum of patients with preeclampsia, but there are no data available on the significance of urinary VCAM-1 excretion in preeclampsia. The aim of our study was to uncover possible circadian rhythms of VCAM-1 plasma levels and urinary VCAM-1 excretion in uncomplicated and hypertensive pregnancies and to ascertain their relation to blood pressure. Study design : A total of 10 normotensive and 10 preeclamptic pregnant women were included in this study. Venous blood was collected hourly, and urine samples were taken every 2 h over a period of 24 h. VCAM-1 levels were determined by ELISA. We compared these results with the circadian blood pressure rhythm. Results : The median VCAM-1 plasma levels were significantly (P<0.01) increased in preeclamptic patients (851.5 ng/mL) in comparison to normotensive pregnant women (659.3 ng/mL) without any circadian rhythm being apparent; however, the urinary excretion of VCAM-1 showed a typical circadian rhythm, with a higher excretion rate during daytime. Conclusion : For the first time we have demonstrated that urinary VCAM-1 excretion in pregnancy shows a circadian rhythm without correlation to plasma levels or the circadian blood pressure rhythm. In contrast, VCAM-1 serum levels did not show a diurnal rhythm. We assume that VCAM-1 serum levels do not correlate with systemic blood pressure or urinary excretion. |
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| Item Description: | Gesehen am 07.04.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1619-3997 |
| DOI: | 10.1515/JPM.2005.027 |