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Day-night variation in the in vitro contractility of aorta and mesenteric and renal arteries in transgenic hypertensive rats

TGR(mREN2)27 (TGR) rats develop severe hypertension and an inverted circadian blood pressure profile with peak blood pressure in the daytime rest phase. The present study investigated the in vitro responsiveness of different arteries of TGR rats during day and night. Twelve-week-old TGR rats and nor...

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Main Authors: Witte, Klaus (Author) , Hasenberg, Till (Author) , Rueff, Thomas (Author) , Hauptfleisch, Stefan (Author) , Schilling, Lothar (Author) , Lemmer, Björn (Author)
Format: Article (Journal) Conference Paper
Language:English
Published: 2001
In: Chronobiology international
Year: 2001, Volume: 18, Issue: 4, Pages: 665-681
ISSN:1525-6073
DOI:10.1081/CBI-100106080
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1081/CBI-100106080
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Author Notes:Klaus Witte, Till Hasenberg, Thomas Rueff, Stefan Hauptfleisch, Lothar Schilling, and Björn Lemmer
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Summary:TGR(mREN2)27 (TGR) rats develop severe hypertension and an inverted circadian blood pressure profile with peak blood pressure in the daytime rest phase. The present study investigated the in vitro responsiveness of different arteries of TGR rats during day and night. Twelve-week-old TGR rats and normotensive Sprague-Dawley (SPRD) controls, synchronized to 12h light, 12h dark (LD 12:12) (light 07:00 19:00), were killed at 09:00 (during rest) and 21:00 (during activity), and endothelium-dependent relaxation by acetylcholine and vascular contraction by angiotensin II were studied by measuring isometric force in ring segments of abdominal aorta and mesenteric and renal arteries. In SPRD rats, consistent day-night variation was found, with greater responses to angiotensin II during the daytime rest span. In TGR rats, biological time-dependent differences were found in the renal vasculature, but not in the aorta and mesenteric artery. Relaxation of SPRD rat aorta and mesenteric artery by acetylcholine was greater at 09:00, whereas in TGR rats, day-night variation was absent (mesenteric artery) or inverted (aorta). In conclusion, based on the study of two time points, daynight variation in vascular contractility of aorta and mesenteric artery is blunted in TGR rats, whereas renal artery segments showed an unchanged daynight pattern compared to SPRD controls.
Item Description:Published online: 07 Jul 2009
Elektronische Reproduktion der Druck-Ausgabe
Part of this work was presented at the International Congress on Chronobiology, Washington, DC, August 28-September 1, 1999
Gesehen am 11.04.2022
Physical Description:Online Resource
ISSN:1525-6073
DOI:10.1081/CBI-100106080

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