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Normalisation of blood pressure in hypertensive TGR(mREN2)27 rats by amlodipine vs. enalapril: effects on cardiac hypertrophy and signal transduction pathways

It is still a controversial issue whether different classes of antihypertensive drugs are equally effective in the regression of cardiac hypertrophy and associated complications. The present study compared the effects of prolonged treatment with the Ca2+-channel blocker amlodipine and the ACE inhibi...

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Bibliographic Details
Main Authors: Witte, Klaus (Author) , Huser, Lutz (Author) , Knotter, Bianca (Author) , Heckmann, Markus (Author) , Schiffer, Sabine (Author) , Lemmer, Björn (Author)
Format: Article (Journal)
Language:English
Published: 2001
In: Naunyn-Schmiedeberg's archives of pharmacology
Year: 2001, Volume: 363, Issue: 1, Pages: 101-109
ISSN:1432-1912
DOI:10.1007/s002100000343
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s002100000343
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Author Notes:Klaus Witte, Lutz Huser, Bianca Knotter, Markus Heckmann, Sabine Schiffer, Björn Lemmer
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Summary:It is still a controversial issue whether different classes of antihypertensive drugs are equally effective in the regression of cardiac hypertrophy and associated complications. The present study compared the effects of prolonged treatment with the Ca2+-channel blocker amlodipine and the ACE inhibitor enalapril, respectively, in TGR(mREN2)27 rats (TGR), an animal model of renin-dependent hypertension.
Item Description:Published online: 26 October 2000
Gesehen am 11.04.2022
Physical Description:Online Resource
ISSN:1432-1912
DOI:10.1007/s002100000343

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