A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

UNC5B is a Netrin-1 receptor expressed in endothelial cells that in the absence of ligand induces apoptosis. Here the authors identify an UNC5B splicing isoform that is insensitive to the pro-survival ligand Netrin-1 and is required for apoptosis-dependent blood vessel development.

Bibliographic Details

Main Authors:	Pradella, Davide (Author) , Deflorian, Gianluca (Author) , Pezzotta, Alex (Author) , Di Matteo, Anna (Author) , Belloni, Elisa (Author) , Campolungo, Daniele (Author) , Paradisi, Andrea (Author) , Bugatti, Mattia (Author) , Vermi, William (Author) , Campioni, Matteo (Author) , Chiapparino, Antonella (Author) , Scietti, Luigi (Author) , Forneris, Federico (Author) , Giampietro, Costanza (Author) , Volf, Nina (Author) , Rehman, Michael (Author) , Zacchigna, Serena (Author) , Paronetto, Maria Paola (Author) , Pistocchi, Anna (Author) , Eichmann, Anne (Author) , Mehlen, Patrick (Author) , Ghigna, Claudia (Author)
Format:	Article (Journal)
Language:	English
Published:	11 August 2021
In:	Nature Communications Year: 2021, Volume: 12, Pages: 1-17
ISSN:	2041-1723
DOI:	10.1038/s41467-021-24998-6
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-021-24998-6 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-021-24998-6
Author Notes:	Davide Pradella, Gianluca Deflorian, Alex Pezzotta, Anna Di Matteo, Elisa Belloni, Daniele Campolungo, Andrea Paradisi, Mattia Bugatti, William Vermi, Matteo Campioni, Antonella Chiapparino, Luigi Scietti, Federico Forneris, Costanza Giampietro, Nina Volf, Michael Rehman, Serena Zacchigna, Maria Paola Paronetto, Anna Pistocchi, Anne Eichmann, Patrick Mehlen & Claudia Ghigna