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Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?

A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free...

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Bibliographische Detailangaben
Hauptverfasser: Combs, Stephanie (VerfasserIn) , Rieken, Stefan (VerfasserIn) , Wick, Wolfgang (VerfasserIn) , Abdollahi, Amir (VerfasserIn) , Deimling, Andreas von (VerfasserIn) , Debus, Jürgen (VerfasserIn) , Hartmann, Christian (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2011
In: Radiation oncology
Year: 2011, Jahrgang: 6, Pages: 1-5
ISSN:1748-717X
DOI:10.1186/1748-717X-6-115
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1748-717X-6-115
Verlag, kostenfrei, Volltext: https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-6-115
Volltext
Verfasserangaben:Stephanie E. Combs, Stefan Rieken, Wolfgang Wick, Amir Abdollahi, Andreas von Deimling, Jürgen Debus, and Christian Hartmann
Beschreibung
Zusammenfassung:A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that methylation. IDH-1 mutations were significantly associated with increased overall survival.
Beschreibung:Gesehen am 14.04.2022
Beschreibung:Online Resource
ISSN:1748-717X
DOI:10.1186/1748-717X-6-115

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