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Treatment of patients with a history of heparin-induced thrombocytopenia and anti-lepirudin antibodies with argatroban

Patients with heparin-induced thrombocytopenia (HIT) type II require anticoagulation with non-heparin immediate acting anticoagulants. Danaparoid may cross react with HIT-antibodies and lepirudin may generate anti-lepirudin antibodies influencing anticoagulation. We hypothesised, that the synthetic...

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Bibliographic Details
Main Authors: Harenberg, Job (Author) , Jörg, Ingrid (Author) , Fenyvesi, Tivadar (Author) , Piazolo, Lukas (Author)
Format: Article (Journal)
Language:English
Published: 2005
In: Journal of thrombosis and thrombolysis
Year: 2005, Volume: 19, Issue: 1, Pages: 65-69
ISSN:1573-742X
DOI:10.1007/s11239-005-0942-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11239-005-0942-4
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Author Notes:Harenberg Job, Jörg Ingrid, Fenyvesi Tivadar, Piazolo Lukas
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Summary:Patients with heparin-induced thrombocytopenia (HIT) type II require anticoagulation with non-heparin immediate acting anticoagulants. Danaparoid may cross react with HIT-antibodies and lepirudin may generate anti-lepirudin antibodies influencing anticoagulation. We hypothesised, that the synthetic small molecular thrombin inhibitor argatroban does not induce immunoglobulins reacting towards lepirudin in patients with anti-lepirudin antibodies in the history and that titration of the anticoagulation may be easier with argatroban.
Item Description:Gesehen am 20.04.2022
Physical Description:Online Resource
ISSN:1573-742X
DOI:10.1007/s11239-005-0942-4

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