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Treatment of patients with a history of heparin-induced thrombocytopenia and anti-lepirudin antibodies with argatroban

Patients with heparin-induced thrombocytopenia (HIT) type II require anticoagulation with non-heparin immediate acting anticoagulants. Danaparoid may cross react with HIT-antibodies and lepirudin may generate anti-lepirudin antibodies influencing anticoagulation. We hypothesised, that the synthetic...

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Hauptverfasser: Harenberg, Job (VerfasserIn) , Jörg, Ingrid (VerfasserIn) , Fenyvesi, Tivadar (VerfasserIn) , Piazolo, Lukas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2005
In: Journal of thrombosis and thrombolysis
Year: 2005, Jahrgang: 19, Heft: 1, Pages: 65-69
ISSN:1573-742X
DOI:10.1007/s11239-005-0942-4
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11239-005-0942-4
Volltext
Verfasserangaben:Harenberg Job, Jörg Ingrid, Fenyvesi Tivadar, Piazolo Lukas
Beschreibung
Zusammenfassung:Patients with heparin-induced thrombocytopenia (HIT) type II require anticoagulation with non-heparin immediate acting anticoagulants. Danaparoid may cross react with HIT-antibodies and lepirudin may generate anti-lepirudin antibodies influencing anticoagulation. We hypothesised, that the synthetic small molecular thrombin inhibitor argatroban does not induce immunoglobulins reacting towards lepirudin in patients with anti-lepirudin antibodies in the history and that titration of the anticoagulation may be easier with argatroban.
Beschreibung:Gesehen am 20.04.2022
Beschreibung:Online Resource
ISSN:1573-742X
DOI:10.1007/s11239-005-0942-4

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