Treatment of patients with a history of heparin-induced thrombocytopenia and anti-lepirudin antibodies with argatroban
Patients with heparin-induced thrombocytopenia (HIT) type II require anticoagulation with non-heparin immediate acting anticoagulants. Danaparoid may cross react with HIT-antibodies and lepirudin may generate anti-lepirudin antibodies influencing anticoagulation. We hypothesised, that the synthetic...
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| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2005
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| In: |
Journal of thrombosis and thrombolysis
Year: 2005, Jahrgang: 19, Heft: 1, Pages: 65-69 |
| ISSN: | 1573-742X |
| DOI: | 10.1007/s11239-005-0942-4 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11239-005-0942-4
|
| Verfasserangaben: | Harenberg Job, Jörg Ingrid, Fenyvesi Tivadar, Piazolo Lukas |
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| 520 | |a Patients with heparin-induced thrombocytopenia (HIT) type II require anticoagulation with non-heparin immediate acting anticoagulants. Danaparoid may cross react with HIT-antibodies and lepirudin may generate anti-lepirudin antibodies influencing anticoagulation. We hypothesised, that the synthetic small molecular thrombin inhibitor argatroban does not induce immunoglobulins reacting towards lepirudin in patients with anti-lepirudin antibodies in the history and that titration of the anticoagulation may be easier with argatroban. | ||
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