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Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1

Spinocerebellar ataxia 1 is a neurodegenerative disease caused by a CAG trinucleotide expansion in the ATXN1 gene encoding the protein ataxin-1. Puneet Opal and his colleagues find that ataxin-1 represses the expression of the angiogenic and neurotrophic factor vascular endothelial growth factor (VE...

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Hauptverfasser: Cvetanovic, Marija (VerfasserIn) , Patel, Jay M. (VerfasserIn) , Marti, Hugo (VerfasserIn) , Kini, Ameet R. (VerfasserIn) , Opal, Puneet (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 October 2011
In: Nature medicine
Year: 2011, Jahrgang: 17, Heft: 11, Pages: 1445-1447
ISSN:1546-170X
DOI:10.1038/nm.2494
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nm.2494
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm.2494
Volltext
Verfasserangaben:Marija Cvetanovic, Jay M. Patel, Hugo H. Marti, Ameet R. Kini & Puneet Opal
Beschreibung
Zusammenfassung:Spinocerebellar ataxia 1 is a neurodegenerative disease caused by a CAG trinucleotide expansion in the ATXN1 gene encoding the protein ataxin-1. Puneet Opal and his colleagues find that ataxin-1 represses the expression of the angiogenic and neurotrophic factor vascular endothelial growth factor (VEGF) and that VEGF levels are decreased in animals with motor impairment. Overexpression or infusion of VEGF improves motor performance and pathology, suggesting VEGF may have therapeutic potential in this disease.
Beschreibung:Gesehen am 25.04.2022
Beschreibung:Online Resource
ISSN:1546-170X
DOI:10.1038/nm.2494

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