Improved laboratory confirmation of heparin-induced thrombocytopenia type II: time course of antibodies and combination of antigen and biologic assays
We studied whether laboratory confirmation of heparin-induced thrombocytopenia (HIT) can be improved after antigen clearance by determining free antibody and combining the results of an antigenic and a biologic assay. Blood samples taken over 40 days in 14 patients with HIT with thromboembolism unde...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
03 January 2001
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| In: |
American journal of clinical pathology
Year: 2001, Volume: 115, Issue: 3, Pages: 432-438 |
| ISSN: | 1943-7722 |
| DOI: | 10.1309/ET2W-5J8E-MFVU-QYAH |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1309/ET2W-5J8E-MFVU-QYAH
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| Author Notes: | Job Harenberg, Lianchun Wang, Ursula Hoffmann, Günter Huhle, Martin Feuring |
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| 520 | |a We studied whether laboratory confirmation of heparin-induced thrombocytopenia (HIT) can be improved after antigen clearance by determining free antibody and combining the results of an antigenic and a biologic assay. Blood samples taken over 40 days in 14 patients with HIT with thromboembolism underwent fluorescence-linked immunofiltration and the carbon 14-serotonin release assays.Of the 14 patients, 11 showed positive results in both assays at day 1 after stopping heparin. The 3 patients with negative results seroconverted in one or both assays during the subsequent 7 days. Combining the positive results of the assays increased the sensitivity from 85% at day 1 to 100% at day 7. Assay results became negative in all patients within 40 days. The platelet count normalized between days 2 and 9 after withdrawal of heparin. It is assumed that the free antibody can be detected after withdrawal of heparin and after clearance of the platelet factor 4-heparin complex in patients with HIT. | ||
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