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Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant

Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, t...

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Main Authors: Erk, Susanne (Author) , Meyer-Lindenberg, Andreas (Author) , Boberfeld, Carola Opitz von (Author) , Esslinger, Christine (Author) , Schnell, Knut (Author) , Kirsch, Peter (Author) , Mattheisen, Manuel (Author) , Mühleisen, Thomas W. (Author) , Cichon, Sven (Author) , Witt, Stephanie H. (Author) , Rietschel, Marcella (Author) , Nöthen, Markus M. (Author) , Walter, Henrik (Author)
Format: Article (Journal)
Language:English
Published: December 7, 2011
In: The journal of neuroscience
Year: 2011, Volume: 31, Issue: 49, Pages: 18180-18184
ISSN:1529-2401
DOI:10.1523/JNEUROSCI.4960-11.2011
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1523/JNEUROSCI.4960-11.2011
Verlag, lizenzpflichtig, Volltext: https://www.jneurosci.org/content/31/49/18180
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Author Notes:Susanne Erk, Andreas Meyer-Lindenberg, Carola Opitz von Boberfeld, Christine Esslinger, Knut Schnell, Peter Kirsch, Manuel Mattheisen, Thomas W. Mühleisen, Sven Cichon, Stephanie H. Witt, Marcella Rietschel, Markus M. Nöthen, Henrik Walter
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Summary:Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection.
Item Description:Gesehen am 02.05.2022
Physical Description:Online Resource
ISSN:1529-2401
DOI:10.1523/JNEUROSCI.4960-11.2011

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