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Balloon valvuloplasty in the treatment of congenital aortic valve stenosis - a retrospective multicenter survey of more than 1000 patients

Background - The value of balloon valvuloplasty of the aortic valve in childhood is still under debate. - Objective - To evaluate the results of the procedure in a retrospective multicenter survey of a large cohort over a long time interval. - Methods - Retrospective analysis of 1004 patients with b...

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Main Authors: Ewert, Peter (Author) , Bertram, H. (Author) , Breuer, J. (Author) , Dähnert, I. (Author) , Dittrich, S. (Author) , Eicken, A. (Author) , Emmel, M. (Author) , Fischer, G. (Author) , Gitter, R. (Author) , Gorenflo, Matthias (Author) , Haas, N. (Author) , Kitzmüller, E. (Author) , Koch, A. (Author) , Kretschmar, O. (Author) , Lindinger, A. (Author) , Michel-Behnke, I. (Author) , Nuernberg, J. H. (Author) , Peuster, M. (Author) , Walter, K. (Author) , Zartner, P. (Author) , Uhlemann, F. (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: International journal of cardiology
Year: 2011, Volume: 149, Issue: 2, Pages: 182-185
ISSN:1874-1754
DOI:10.1016/j.ijcard.2010.01.005
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijcard.2010.01.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167527310000252
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Author Notes:P. Ewert, H. Bertram, J. Breuer, I. Dähnert, S. Dittrich, A. Eicken, M. Emmel, G. Fischer, R. Gitter, M. Gorenflo, N. Haas, E. Kitzmüller, A. Koch, O. Kretschmar, A. Lindinger, I. Michel-Behnke, J.H. Nuernberg, M. Peuster, K. Walter, P. Zartner, F. Uhlemann
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Summary:Background - The value of balloon valvuloplasty of the aortic valve in childhood is still under debate. - Objective - To evaluate the results of the procedure in a retrospective multicenter survey of a large cohort over a long time interval. - Methods - Retrospective analysis of 1004 patients with balloon valvuloplasty of the aortic valve performed between 9/1985 and 10/2006 at 20 centers in Germany, Austria and Switzerland. Amongst others, the following parameters were evaluated before and after the procedure as well as at the end of follow-up or before surgery: clinical status, left ventricular function, transaortic pressure gradient, degree of aortic regurgitation, freedom from re-intervention or surgery. - Patients - Patients from 1day to 18years of age with aortic valve stenosis were divided into four groups: 334 newborns (1-28days); 249 infants (29-365days); 211 children (1-10years), and 210 adolescents (10-18years). - Results - Median follow-up was 32months (0days to 17.5years). After dilatation the pressure gradient decreased from 65 (±24)mm Hg to 26 (±16)mm Hg and remained stable during follow-up. The newborns were the most affected patients. Approximately 60% of them had clinical symptoms and impaired left ventricular function before intervention. Complication rate was 15% in newborns, 11% in infants and 6% in older children. Independently of age, 50% of all patients were free from surgery 10years after intervention. - Conclusions - In this retrospective multicenter study, balloon valvuloplasty of the aortic valve has effectively postponed the need for surgery in infants, children and adolescents up to 18years of age.
Item Description:Available online 11 February 2010
Gesehen am 02.05.2022
Physical Description:Online Resource
ISSN:1874-1754
DOI:10.1016/j.ijcard.2010.01.005

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