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Pivotal antitumor role of the immune checkpoint molecule B7-H1 in pancreatic cancer

Immune checkpoint molecule B7-H1 plays a decisive immune regulatory role in different pathologies including cancer, and manipulation of B7-H1 expression became an attractive approach in cancer immunotherapy. Pancreatic cancer (PDAC) is characterized by pronounced immunosuppressive environment and B7...

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Main Authors: Bazhin, Alexandr V. (Author) , Ahn, Katharina von (Author) , Fritz, Jasmin (Author) , Bunge, Henriette (Author) , Maier, Caroline (Author) , Isayev, Orkhan (Author) , Neff, Florian Matthias (Author) , Siveke, Jens T. (Author) , Karakhanova, Svetlana (Author)
Format: Article (Journal)
Language:English
Published: 01 Mar 2022
In: OncoImmunology
Year: 2022, Volume: 11, Issue: 1, Pages: 1-14
ISSN:2162-402X
DOI:10.1080/2162402X.2022.2043037
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/2162402X.2022.2043037
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Author Notes:Alexandr V. Bazhin, Katharina von Ahn, Jasmin Fritz, Henriette Bunge, Caroline Maier, Orkhan Isayev, Florian Neff, Jens T. Siveke & Svetlana Karakhanova
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Summary:Immune checkpoint molecule B7-H1 plays a decisive immune regulatory role in different pathologies including cancer, and manipulation of B7-H1 expression became an attractive approach in cancer immunotherapy. Pancreatic cancer (PDAC) is characterized by pronounced immunosuppressive environment and B7-H1 expression correlates with PDAC prognosis. However, the first attempts to diminish B7-H1 expression in patients were not so successful. This points the complicity of PDAC immunosuppressive network and requires further examinations. We investigated the effect of B7-H1 deficiency in PDAC. Our results clearly show that partial or complete B7-H1 inhibition in vivo let to reduced tumor volume and improved survival of PDAC-bearing mice. This oncological benefit is due to the abrogation of immunosuppression provided by MDSC, macrophages, DC and Treg, which resulted in simultaneous restoration of anti-tumor immune response, namely improved accumulation and functionality of effector-memory CD4 and CD8 T cells. Our results underline the potential of B7-H1 molecule to control immunosuppressive network in PDAC and provide new issues for further clinical investigations.
Item Description:Gesehen am 02.05.2022
Physical Description:Online Resource
ISSN:2162-402X
DOI:10.1080/2162402X.2022.2043037

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