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Leukocytoclastic vasculitis and acute renal failure after influenza vaccination in an elderly patient with myelodysplastic syndrome

Influenza vaccination is recommended for individuals over 65 years of age and for all patients with chronic diseases who are at risk. Side effects which are seen in 1-10% of the vaccinated individuals are usually mild and consist of local reactions and constitutional symptoms. Since 1974, about 30 c...

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Main Authors: Ulm, Silke (Author) , Hummel, Margit (Author) , Emig, Michael (Author) , Barreto Miranda, Manuel (Author) , Back, Walter (Author) , Reiter, Andreas (Author) , Hehlmann, Rüdiger (Author) , Willer, Andreas (Author)
Format: Article (Journal)
Language:English
Published: September 27, 2006
In: Onkologie
Year: 2006, Volume: 29, Issue: 10, Pages: 470-472
ISSN:1423-0240
DOI:10.1159/000095412
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000095412
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/95412
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Author Notes:Silke Ulm, Margit Hummel, Michael Emig, Manuel Barreto-Miranda, Walter Back, Andreas Reiter, Rüdiger Hehlmann, Andreas Willer
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Summary:Influenza vaccination is recommended for individuals over 65 years of age and for all patients with chronic diseases who are at risk. Side effects which are seen in 1-10% of the vaccinated individuals are usually mild and consist of local reactions and constitutional symptoms. Since 1974, about 30 cases of vasculitis following influenza vaccination have been reported. Case Report: We here describe a 70-year-old male patient with a 5-year history of myelodysplastic syndrome, who had received continuous steroid treatment since 2004 and presented with leukocytoclastic vasculitis and acute renal failure requiring hemodialysis therapy 1 week after influenza vaccination. High-dose steroid treatment was promptly initiated, but hemodialysis was needed for 9 days. Maintained steroid treatment for 2 weeks was associated with complete recovery of renal function and skin lesions. Conclusion: As influenza vaccination is increasingly used, physicians should be aware of the potential serious side effect of leukocytoclastic vasculitis, particularly in patients who are immunocompromised either due to an underlying disorder or as a treatmentrelated side effect.
Item Description:Gesehen am 10.05.2022
Physical Description:Online Resource
ISSN:1423-0240
DOI:10.1159/000095412

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