Buchumschlag

Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis

Atherosclerosis is studied in models with dysfunctional lipid homeostasis—predominantly the ApoE−/− mouse. The role of antigen-presenting cells (APCs) for lipid homeostasis is not clear. Using a LacZ reporter mouse, we showed that CD11c+ cells were enriched in aortae of ApoE−/− mice. Systemic long-t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Sauter, Manuela (VerfasserIn) , Sauter, Reinhard J. (VerfasserIn) , Nording, Henry (VerfasserIn) , Lin, Chaolan (VerfasserIn) , Olbrich, Marcus (VerfasserIn) , Autenrieth, Stella (VerfasserIn) , Gleißner, Christian A. (VerfasserIn) , Thunemann, Martin (VerfasserIn) , Otero, Nadia (VerfasserIn) , Lutgens, Esther (VerfasserIn) , Aherrahrou, Zouhair (VerfasserIn) , Wolf, Dennis (VerfasserIn) , Zender, Lars (VerfasserIn) , Meuth, Sven (VerfasserIn) , Feil, Robert (VerfasserIn) , Langer, Harald F. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2022
In: iScience
Year: 2022, Jahrgang: 25, Heft: 1, Pages: 1-20
ISSN:2589-0042
DOI:10.1016/j.isci.2021.103677
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.isci.2021.103677
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2589004221016473
Volltext
Verfasserangaben:Manuela Sauter, Reinhard J. Sauter, Henry Nording, Chaolan Lin, Marcus Olbrich, Stella Autenrieth, Christian Gleissner, Martin Thunemann, Nadia Otero, Esther Lutgens, Zouhair Aherrahrou, Dennis Wolf, Lars Zender, Sven Meuth, Robert Feil, and Harald F. Langer
Beschreibung
Zusammenfassung:Atherosclerosis is studied in models with dysfunctional lipid homeostasis—predominantly the ApoE−/− mouse. The role of antigen-presenting cells (APCs) for lipid homeostasis is not clear. Using a LacZ reporter mouse, we showed that CD11c+ cells were enriched in aortae of ApoE−/− mice. Systemic long-term depletion of CD11c+ cells in ApoE−/− mice resulted in significantly increased plaque formation associated with reduced serum ApoE levels. In CD11ccre+ApoEfl/fl and Albumincre+ApoEfl/fl mice, we could show that ≈70% of ApoE is liver-derived and ≈25% originates from CD11c+ cells associated with significantly increased atherosclerotic plaque burden in both strains. Exposure to acLDL promoted cholesterol efflux from CD11c+ cells and cell-specific deletion of ApoE resulted in increased inflammation reflected by increased IL-1β serum levels. Our results determined for the first time the level of ApoE originating from CD11c+ cells and demonstrated that CD11c+ cells ameliorate atherosclerosis by the secretion of ApoE.
Beschreibung:Available online 25 December 2021
Im Titel ist das Pluszeichen "+" hochgestellt
Gesehen am 11.05.2022
Beschreibung:Online Resource
ISSN:2589-0042
DOI:10.1016/j.isci.2021.103677

Ähnliche Einträge