Fluoride status and cardiometabolic health: findings from a representative survey among children and adolescents
There is preliminary evidence to suggest a positive association between fluoride exposure and higher blood pressure among children, but population-based biomarker studies are lacking. Thus, data from the 2013/2014 and 2015/2016 cycles of the US-based National Health and Nutrition Examination Survey...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
31 March 2022
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| In: |
Nutrients
Year: 2022, Volume: 14, Issue: 7, Pages: 1-9 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu14071459 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/nu14071459 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6643/14/7/1459 
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| Author Notes: | Jessica A. Ballantyne, Gemma Coyle, Sneha Sarwar and Tilman Kühn |
| Summary: | There is preliminary evidence to suggest a positive association between fluoride exposure and higher blood pressure among children, but population-based biomarker studies are lacking. Thus, data from the 2013/2014 and 2015/2016 cycles of the US-based National Health and Nutrition Examination Survey (NHANES) were analysed to evaluate the association between plasma fluoride concentrations and blood pressure among children and adolescents aged 8 to 19 years. Secondary analyses were carried out on fluoride status in relation to further markers of cardio-metabolic health, i.e., anthropometric indices, biomarkers of lipid and sugar metabolism, and C-reactive protein levels. There was a positive correlation between water fluoride content and plasma fluoride concentrations (Spearman’s r = 0.41, p < 0.01). However, multivariable linear regression models did not show significant differences in adjusted mean values of systolic and diastolic blood pressure across increasing quartiles of fluoride concentrations. Further markers of cardio-metabolic health were not associated with fluoride status, with the exception of a weak inverse association between plasma fluoride and HbA1c levels. Higher plasma fluoride may not be a risk factor for increased blood pressure or impaired cardio-metabolic health among children in the USA, a non-fluoride endemic country, with wide-spread water fluoridation. |
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| Item Description: | Gesehen am 13.05.2022 |
| Physical Description: | Online Resource |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu14071459 |