Cover Image

Association of habitual dietary intake with liver iron: a population-based imaging study

Iron-related disorders of the liver can result in serious health conditions, such as liver cirrhosis. Evidence on the role of modifiable lifestyle factors like nutrition in liver iron storage is lacking. Thus, we aimed to assess the association of habitual diet with liver iron content (LIC). We inve...

Full description

Saved in:
Bibliographic Details
Main Authors: Filler, Jule (Author) , Krüchten, Ricarda von (Author) , Wawro, Nina (Author) , Maier, Lisa (Author) , Lorbeer, Roberto (Author) , Nattenmüller, Johanna (Author) , Thorand, Barbara (Author) , Bamberg, Fabian (Author) , Peters, Annette (Author) , Schlett, Christopher L. (Author) , Linseisen, Jakob (Author) , Rospleszcz, Susanne (Author)
Format: Article (Journal)
Language:English
Published: 2022
In: Nutrients
Year: 2022, Volume: 14, Issue: 1, Pages: 1-14
ISSN:2072-6643
DOI:10.3390/nu14010132
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/nu14010132
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6643/14/1/132
Get full text
Author Notes:Jule Filler, Ricarda von Krüchten, Nina Wawro, Lisa Maier, Roberto Lorbeer, Johanna Nattenmüller, Barbara Thorand, Fabian Bamberg, Annette Peters, Christopher L. Schlett, Jakob Linseisen and Susanne Rospleszcz
Description
Summary:Iron-related disorders of the liver can result in serious health conditions, such as liver cirrhosis. Evidence on the role of modifiable lifestyle factors like nutrition in liver iron storage is lacking. Thus, we aimed to assess the association of habitual diet with liver iron content (LIC). We investigated 303 participants from the population-based KORA-MRI study who underwent whole-body magnetic resonance imaging (MRI). Dietary habits were evaluated using repeated 24 h food lists and a food frequency questionnaire. Sex-stratified multiple linear regression models were applied to quantify the association between nutrition variables of interest and LIC, adjusting for liver fat content (LFC), energy intake, and age. Mean age of participants was 56.4 ± 9.0 years and 44.2% were female. Mean LIC was 1.23 ± 0.12 mg/g dry weight, with higher values in men than in women (1.26 ± 0.13 and 1.20 ± 0.10 mg/g, p < 0.001). Alcohol intake was positively associated with LIC (men: β = 1.94; women: β = 4.98, p-values < 0.03). Significant negative associations with LIC were found for fiber (β = −5.61, p < 0.001) and potassium (β = −0.058, p = 0.034) for female participants only. Furthermore, LIC was highly correlated with liver fat content in both sexes. Our findings suggests that there are sex-specific associations of habitual dietary intake and LIC. Alcohol, fiber, and potassium may play a considerable role in liver iron metabolism.
Item Description:Published: 28 December 2021
Gesehen am 13.05.2022
Physical Description:Online Resource
ISSN:2072-6643
DOI:10.3390/nu14010132

Similar Items