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NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels

Fully functional regeneration of skeletal defects by multipotent progenitor cells requires that differentiating cells gain the specific mechano-competence needed in the target tissue. Using cartilage neogenesis as an example, we asked whether proper phenotypic differentiation of mesenchymal stromal...

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Bibliographic Details
Main Authors: Lückgen, Janine (Author) , Raqué, Elisabeth (Author) , Reiner, Tobias (Author) , Diederichs, Solvig (Author) , Richter, Wiltrud (Author)
Format: Article (Journal)
Language:English
Published: 27 April 2022
In: Stem cell research & therapy
Year: 2022, Volume: 13, Issue: 1, Pages: 1-15
ISSN:1757-6512
DOI:10.1186/s13287-022-02843-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13287-022-02843-x
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Author Notes:Janine Lückgen, Elisabeth Raqué, Tobias Reiner, Solvig Diederichs and Wiltrud Richter
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Summary:Fully functional regeneration of skeletal defects by multipotent progenitor cells requires that differentiating cells gain the specific mechano-competence needed in the target tissue. Using cartilage neogenesis as an example, we asked whether proper phenotypic differentiation of mesenchymal stromal cells (MSC) into chondrocytes in vitro will install the adequate biological mechano-competence of native articular chondrocytes (AC).
Item Description:Gesehen am 17.05.2022
Physical Description:Online Resource
ISSN:1757-6512
DOI:10.1186/s13287-022-02843-x

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