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Effects of vitamin D supplementation on 24-hour blood pressure in patients with low 25-hydroxyvitamin D levels: a randomized controlled trial

Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analys...

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Main Authors: Theiler-Schwetz, Verena (Author) , Trummer, Christian (Author) , Grübler, Martin R. (Author) , Keppel, Martin H. (Author) , Zittermann, Armin (Author) , Tomaschitz, Andreas (Author) , Karras, Spyridon N. (Author) , März, Winfried (Author) , Pilz, Stefan (Author) , Gängler, Stephanie (Author)
Format: Article (Journal)
Language:English
Published: 24 March 2022
In: Nutrients
Year: 2022, Volume: 14, Issue: 7, Pages: 1-12
ISSN:2072-6643
DOI:10.3390/nu14071360
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/nu14071360
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6643/14/7/1360
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Author Notes:Verena Theiler-Schwetz, Christian Trummer, Martin R. Grübler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Spyridon N. Karras, Winfried März, Stefan Pilz and Stephanie Gängler
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Summary:Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analysis of the double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011-2014) with 200 hypertensive patients with 25(OH)D levels <30 ng/mL. We evaluated whether 2800 IU of vitamin D3/day or placebo (1:1) for 8 weeks affects 24-hour systolic ambulatory BP in patients with 25(OH)D concentrations <20 ng/mL, <16 ng/mL, and <12 ng/mL and whether achieved 25(OH)D concentrations were associated with BP measures. Taking into account correction for multiple testing, p values < 0.0026 were considered significant. No significant treatment effects on 24-hour BP were observed when different baseline 25(OH)D thresholds were used (all p-values > 0.30). However, there was a marginally significant trend towards an inverse association between the achieved 25(OH)D level with 24-hour systolic BP (−0.196 per ng/mL 25(OH)D, 95% CI (−0.325 to −0.067); p = 0.003). In conclusion, we could not document the antihypertensive effects of vitamin D in vitamin D-deficient individuals, but the association between achieved 25(OH)D concentrations and BP warrants further investigations on cardiovascular benefits of vitamin D in severe vitamin D deficiency.
Item Description:Gesehen am 18.05.2022
Physical Description:Online Resource
ISSN:2072-6643
DOI:10.3390/nu14071360

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