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Cortical glutamate and GABA changes during early abstinence in alcohol dependence and their associations with benzodiazepine medication

In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification (first 2 weeks of abstinence). The focus of t...

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Main Authors: Wang, Guo-Ying (Author) , Weber-Fahr, Wolfgang (Author) , Frischknecht, Ulrich (Author) , Hermann, Derik (Author) , Kiefer, Falk (Author) , Ende, Gabriele (Author) , Sack, Markus (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Frontiers in psychiatry
Year: 2021, Volume: 12, Pages: 1-7
ISSN:1664-0640
DOI:10.3389/fpsyt.2021.656468
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.3389/fpsyt.2021.656468
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/article/10.3389/fpsyt.2021.656468
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Author Notes:Guoying Wang, Wolfgang Weber-Fahr, Ulrich Frischknecht, Derik Hermann, Falk Kiefer, Gabriele Ende and Markus Sack
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Summary:In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification (first 2 weeks of abstinence). The focus of this study was to examine whether the amount of benzodiazepine administered to treat withdrawal symptoms was associated with longitudinal changes in Glu, Glx, and GABA. The tNAA levels served as an internal quality reference; in agreement with the vast majority of previous reports, these levels were initially decreased and normalized during the course of abstinence in ADPs. Our results on Glu and Glx support hyperglutamatergic functioning during alcohol withdrawal, by showing higher ACC Glu and Glx levels on the first day of detoxification in ADPs. Withdrawal severity is reflected in cumulative benzodiazepine requirements throughout the withdrawal period. The importance of withdrawal severity for the study of GABA and Glu changes in early abstinence is emphasized by the benzodiazepine-dependent Glu, Glx, and GABA changes observed during the course of abstinence.
Item Description:05 July 2021
Gesehen am 18.05.2022
Physical Description:Online Resource
ISSN:1664-0640
DOI:10.3389/fpsyt.2021.656468

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