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Expression and activity of matrix metalloproteinases-2 and -9 in serum, core needle biopsies and tissue specimens of prostate cancer patients

Prostate cancer is the most common cancer in men and second in the cancer-related frequency of mortality. Matrix metalloproteinases (MMPs) are involved in tumor invasion and metastasis in various malignancies. MMP-2 and MMP-9 are capable of digesting collagen type IV. Numerous studies have demonstra...

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Main Authors: Sauer, Christian (Author) , Römer, Alexandra (Author) , Späth, Monika (Author) , Kaden, Jens (Author) , Michel, Maurice Stephan (Author) , Mayer, Doris (Author) , Bleyl, Uwe (Author) , Grobholz, Rainer (Author)
Format: Article (Journal)
Language:English
Published: 16 April 2004
In: Virchows Archiv
Year: 2004, Volume: 444, Issue: 6, Pages: 518-526
ISSN:1432-2307
DOI:10.1007/s00428-004-1016-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00428-004-1016-2
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Author Notes:Christian G. Sauer, Alexandra Kappeler, Monika Späth, Jens J. Kaden, Maurice S. Michel, Doris Mayer, Uwe Bleyl, Rainer Grobholz
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Summary:Prostate cancer is the most common cancer in men and second in the cancer-related frequency of mortality. Matrix metalloproteinases (MMPs) are involved in tumor invasion and metastasis in various malignancies. MMP-2 and MMP-9 are capable of digesting collagen type IV. Numerous studies have demonstrated an association between increased MMP-2 and -9 expression and tumor progression in various tumors. In this study, the expression and activities of MMP-2 and -9 were assessed in serum probes and tumor tissue from core needle biopsies and radical prostatectomies of 97 patients. MMP-2 and -9 serum expression was analyzed in a subgroup of 31 patients. MMP-9 serum expression was significantly increased in tumor patients and correlated with tumor grade. In contrast, the MMP-9 tissue expression and activity revealed no significant correlations to tumor stage or grade. The MMP-2 activity, however, showed a positive correlation for MMP-2 with tumor stage. Increased activity was predominantly detected in advanced tumor stages. Immunohistochemical analysis of MMP-2 expression demonstrated a positive association with tumor grade in prostatectomy specimens. The relative expression rates in biopsies matched in 65% with those of the prostatectomies. Detection of MMP-2 in core needle biopsies seems not to be a helpful marker for diagnostic purposes.
Item Description:Gesehen am 31.05.2022
Physical Description:Online Resource
ISSN:1432-2307
DOI:10.1007/s00428-004-1016-2

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