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Symptom severity and health-related quality of life in patients with atrial fibrillation: findings from the observational ARENA study

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with impaired health-related quality of life (HRQoL), high symptom severity, and poor cardiovascular outcomes. Both clinical and psychological factors may contribute to symptom severity and HRQoL i...

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Main Authors: Sadlonova, Monika (Author) , Senges, Jochen (Author) , Nagel, Jonas (Author) , Celano, Christopher (Author) , Klasen-Max, Caroline (Author) , Borggrefe, Martin (Author) , Akın, Ibrahim (Author) , Thomas, Dierk (Author) , Schwarzbach, Christopher Jan (Author) , Kleemann, Thomas (Author) , Schneider, Steffen (Author) , Hochadel, Matthias (Author) , Süselbeck, Tim (Author) , Schwacke, Harald (Author) , Alonso, Angelika (Author) , Haass, Markus (Author) , Ladwig, Karl-Heinz (Author) , Herrmann-Lingen, Christoph (Author)
Format: Article (Journal)
Language:English
Published: 21 February 2022
In: Journal of Clinical Medicine
Year: 2022, Volume: 11, Issue: 4, Pages: 1-15
ISSN:2077-0383
DOI:10.3390/jcm11041140
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/jcm11041140
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2077-0383/11/4/1140
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Author Notes:Monika Sadlonova, Jochen Senges, Jonas Nagel, Christopher Celano, Caroline Klasen-Max, Martin Borggrefe, Ibrahim Akin, Dierk Thomas, Christopher Jan Schwarzbach, Thomas Kleeman, Steffen Schneider, Matthias Hochadel, Tim Süselbeck, Harald Schwacke, Angelika Alonso, Markus Haass, Karl-Heinz Ladwig and Christoph Herrmann-Lingen
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Summary:Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with impaired health-related quality of life (HRQoL), high symptom severity, and poor cardiovascular outcomes. Both clinical and psychological factors may contribute to symptom severity and HRQoL in AF. Methods: Using data from the observational Atrial Fibrillation Rhine-Neckar Region (ARENA) trial, we identified medical and psychosocial factors associated with AF-related symptom severity using European Heart Rhythm Association symptom classification and HRQoL using 5-level EuroQoL- 5D. Results: In 1218 AF patients (mean age 71.1 ± 10.5 years, 34.5% female), female sex (OR 3.7, p < 0.001), preexisting coronary artery disease (CAD) (OR 1.7, p = 0.020), a history of cardioversion (OR 1.4, p = 0.041), cardiac anxiety (OR 1.2; p < 0.001), stress from noise (OR 1.4, p = 0.005), work-related stress (OR 1.3, p = 0.026), and sleep disturbance (OR 1.2, p = 0.016) were associated with higher AF-related symptom severity. CAD (β = −0.23, p = 0.001), diabetes mellitus (β = −0.25, p < 0.001), generalized anxiety (β = −0.30, p < 0.001), cardiac anxiety (β = −0.16, p < 0.001), financial stress (β = −0.11, p < 0.001), and sleep disturbance (β = 0.11, p < 0.001) were associated with impaired HRQoL. Conclusions: Psychological characteristics, preexisting CAD, and diabetes may play an important role in the identification of individuals at highest risk for impaired HRQoL and high symptom severity in patients with AF.
Item Description:Gesehen am 01.06.2022
This article belongs to the special issue "Advances in usual care of coronary artery disease: mechanisms and outcome of cardiologic, exercise, tobacco cessation and psychosocial studies"
Physical Description:Online Resource
ISSN:2077-0383
DOI:10.3390/jcm11041140

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