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The jumping to conclusions reasoning bias as a cognitive factor contributing to psychosis progression and persistence: findings from NEMESIS-2

BackgroundContemporary models of psychosis implicate the importance of affective dysregulation and cognitive factors (e.g. biases and schemas) in the development and maintenance of psychotic symptoms, but studies testing proposed mechanisms remain limited. This study, uniquely using a prospective de...

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Main Authors: Rauschenberg, Christian (Author) , Reininghaus, Ulrich (Author) , Have, Margreet ten (Author) , Graaf, Ron de (Author) , Dorsselaer, Saskia van (Author) , Simons, Claudia J. P. (Author) , Gunther, Nicole (Author) , Henquet, Cécile (Author) , Pries, Lotta-Katrin (Author) , Guloksuz, Sinan (Author) , Bak, Maarten (Author) , Os, Jim van (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Psychological medicine
Year: 2021, Volume: 51, Issue: 10, Pages: 1696-1703
ISSN:1469-8978
DOI:10.1017/S0033291720000446
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1017/S0033291720000446
Verlag, lizenzpflichtig, Volltext: https://www.cambridge.org/core/journals/psychological-medicine/article/jumping-to-conclusions-reasoning-bias-as-a-cognitive-factor-contributing-to-psychosis-progression-and-persistence-findings-from-nemesis2/85F5D0E7B73580B12C4BBC5459DE5950#
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Author Notes:Christian Rauschenberg, Ulrich Reininghaus, Margreet ten Have, Ron de Graaf, Saskia van Dorsselaer, Claudia J. P. Simons, Nicole Gunther, Cécile Henquet, Lotta-Katrin Pries, Sinan Guloksuz, Maarten Bak and Jim van Os
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Summary:BackgroundContemporary models of psychosis implicate the importance of affective dysregulation and cognitive factors (e.g. biases and schemas) in the development and maintenance of psychotic symptoms, but studies testing proposed mechanisms remain limited. This study, uniquely using a prospective design, investigated whether the jumping to conclusions (JTC) reasoning bias contributes to psychosis progression and persistence.MethodsData were derived from the second Netherlands Mental Health Survey and Incidence Study (NEMESIS-2). The Composite International Diagnostic Interview and an add-on instrument were used to assess affective dysregulation (i.e. depression, anxiety and mania) and psychotic experiences (PEs), respectively. The beads task was used to assess JTC bias. Time series analyses were conducted using data from T1 and T2 (N = 8666), excluding individuals who reported high psychosis levels at T0.ResultsAlthough the prospective design resulted in low statistical power, the findings suggest that, compared to those without symptoms, individuals with lifetime affective dysregulation were more likely to progress from low/moderate psychosis levels (state of ‘aberrant salience’, one or two PEs) at T1 to high psychosis levels (‘frank psychosis’, three or more PEs or psychosis-related help-seeking behaviour) at T2 if the JTC bias was present [adj. relative risk ratio (RRR): 3.8, 95% confidence interval (CI) 0.8-18.6, p = 0.101]. Similarly, the JTC bias contributed to the persistence of high psychosis levels (adj. RRR: 12.7, 95% CI 0.7-239.6, p = 0.091).ConclusionsWe found some evidence that the JTC bias may contribute to psychosis progression and persistence in individuals with affective dysregulation. However, well-powered prospective studies are needed to replicate these findings.
Item Description:Published online by Cambridge University Press: 16 March 2020
Gesehen am 08.06.2022
Physical Description:Online Resource
ISSN:1469-8978
DOI:10.1017/S0033291720000446

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