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Pharmacokinetics of 5-Aminofluorescein-Albumin, a novel fluorescence marker of brain tumors during surgery

In a phase I/II study, the new fluorescence marker 5-aminofluorescein covalently bound to human serum albumin (AFL-HSA) was intravenously administered to 10 patients with brain tumor 1 to 4 days before surgery, and AFL-HSA kinetics were determined to assess the optimum timing of dye administration....

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Bibliographic Details
Main Authors: Ding, Reinhard (Author) , Frei, Eva (Author) , Fardanesh, Mahmoudreza (Author) , Schrenk, Hans-Hermann (Author) , Kremer, Paul (Author) , Haefeli, Walter E. (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Journal of clinical pharmacology
Year: 2011, Volume: 51, Issue: 5, Pages: 672-678
ISSN:1552-4604
DOI:10.1177/0091270010372626
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/0091270010372626
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270010372626
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Author Notes:Reinhard Ding, Eva Frei, Mahmoudreza Fardanesh, Hans-Hermann Schrenk, Paul Kremer, and Walter E. Haefeli
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Summary:In a phase I/II study, the new fluorescence marker 5-aminofluorescein covalently bound to human serum albumin (AFL-HSA) was intravenously administered to 10 patients with brain tumor 1 to 4 days before surgery, and AFL-HSA kinetics were determined to assess the optimum timing of dye administration. AFL-HSA was determined in serum and brain tissue by size exclusion chromatography with fluorescence detection. AFL-HSA disposition was quite similar to albumin kinetics with small volumes of distribution (volume of central compartment [Vc] = 2.4 L; volume of distribution [Vdβ] = 6.8 L; volume at steady state [Vss] = 5.9 L), a low clearance (mean Cl = 16.85 mL/h), and a long elimination half-life (mean T½β = 307 hours). Predicted peak concentrations in the peripheral compartment occurred at 80.9 hours, the time point of optimal fluorescence intensity observed in brain tumors during surgery.
Item Description:Elektronische Reproduktion der Druck-Ausgabe
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Physical Description:Online Resource
ISSN:1552-4604
DOI:10.1177/0091270010372626

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