Cover Image

Enucleation is a feasible procedure for well-differentiated pNEN: a matched pair analysis

The extent of surgical resection in the treatment of pancreatic neuroendocrine neoplasms (pNEN) is still controversial. This study aimed to evaluate the outcomes of enucleation for well-differentiated non-functional (nf) pNEN. Patients undergoing enucleation (2001-2020) were analyzed. Clinicopatholo...

Full description

Saved in:
Bibliographic Details
Main Authors: Nießen, Anna (Author) , Bechtiger, Fabiola A. (Author) , Hinz, Ulf (Author) , Lewosinska, Magdalena (Author) , Billmann, Franck (Author) , Hackert, Thilo (Author) , Büchler, Markus W. (Author) , Schimmack, Simon (Author)
Format: Article (Journal)
Language:English
Published: 23 May 2022
In: Cancers
Year: 2022, Volume: 14, Issue: 10, Pages: 1-12
ISSN:2072-6694
DOI:10.3390/cancers14102570
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers14102570
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/14/10/2570
Get full text
Author Notes:Anna Nießen, Fabiola A. Bechtiger, Ulf Hinz, Magdalena Lewosinska, Franck Billmann, Thilo Hackert, Markus W. Büchler and Simon Schimmack
Description
Summary:The extent of surgical resection in the treatment of pancreatic neuroendocrine neoplasms (pNEN) is still controversial. This study aimed to evaluate the outcomes of enucleation for well-differentiated non-functional (nf) pNEN. Patients undergoing enucleation (2001-2020) were analyzed. Clinicopathological parameters, perioperative outcomes and survival were assessed. The analysis was performed as a nested case-control study and matched-pair analysis with formal resection. Sixty-one patients undergoing enucleation were identified. Compared to patients undergoing formal resection, enucleation was associated with a significantly shorter median length of operative time (128 (IQR 95-170) versus 263 (172-337) minutes, p < 0.0001) and a significantly lower rate of postoperative diabetes (2% versus 21%, p = 0.0020). There was no significant difference in postoperative pancreatic fistula rate (18% versus 16% type B/C, p = 1.0), Clavien−Dindo ≥ III complications (20% versus 26%, p = 0.5189), readmission rate (12% versus 15%, p = 0.6022) or length of hospital stay (8 (7-11) versus 10 (8-17) days, p = 0.0652). There was no 30-day mortality after enucleation compared to 1.6% (n = 1) after formal resection. 10-year overall survival (OS) and disease-free survival (DFS) was similar between the two groups (OS: 89% versus 77%, p = 0.2756; DFS: 98% versus 91%, p = 0.0873). Enucleation presents a safe surgical approach for well-differentiated nf-pNEN with good long-term outcomes for selected patients.
Item Description:Gesehen am 23.06.2022
This article belongs to the special issue "Updates on diagnostic and therapeutic management of neuroendocrine neoplasms"
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers14102570

Similar Items