Enucleation is a feasible procedure for well-differentiated pNEN: a matched pair analysis
The extent of surgical resection in the treatment of pancreatic neuroendocrine neoplasms (pNEN) is still controversial. This study aimed to evaluate the outcomes of enucleation for well-differentiated non-functional (nf) pNEN. Patients undergoing enucleation (2001-2020) were analyzed. Clinicopatholo...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 May 2022
|
| In: |
Cancers
Year: 2022, Volume: 14, Issue: 10, Pages: 1-12 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers14102570 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers14102570 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/14/10/2570 
|
| Author Notes: | Anna Nießen, Fabiola A. Bechtiger, Ulf Hinz, Magdalena Lewosinska, Franck Billmann, Thilo Hackert, Markus W. Büchler and Simon Schimmack |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1807581489 | ||
| 003 | DE-627 | ||
| 005 | 20230427155719.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220623s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers14102570 |2 doi | |
| 035 | |a (DE-627)1807581489 | ||
| 035 | |a (DE-599)KXP1807581489 | ||
| 035 | |a (OCoLC)1341461684 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Nießen, Anna |d 1987- |e VerfasserIn |0 (DE-588)1101590475 |0 (DE-627)859774899 |0 (DE-576)46995079X |4 aut | |
| 245 | 1 | 0 | |a Enucleation is a feasible procedure for well-differentiated pNEN |b a matched pair analysis |c Anna Nießen, Fabiola A. Bechtiger, Ulf Hinz, Magdalena Lewosinska, Franck Billmann, Thilo Hackert, Markus W. Büchler and Simon Schimmack |
| 264 | 1 | |c 23 May 2022 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.06.2022 | ||
| 500 | |a This article belongs to the special issue "Updates on diagnostic and therapeutic management of neuroendocrine neoplasms" | ||
| 520 | |a The extent of surgical resection in the treatment of pancreatic neuroendocrine neoplasms (pNEN) is still controversial. This study aimed to evaluate the outcomes of enucleation for well-differentiated non-functional (nf) pNEN. Patients undergoing enucleation (2001-2020) were analyzed. Clinicopathological parameters, perioperative outcomes and survival were assessed. The analysis was performed as a nested case-control study and matched-pair analysis with formal resection. Sixty-one patients undergoing enucleation were identified. Compared to patients undergoing formal resection, enucleation was associated with a significantly shorter median length of operative time (128 (IQR 95-170) versus 263 (172-337) minutes, p < 0.0001) and a significantly lower rate of postoperative diabetes (2% versus 21%, p = 0.0020). There was no significant difference in postoperative pancreatic fistula rate (18% versus 16% type B/C, p = 1.0), Clavien−Dindo ≥ III complications (20% versus 26%, p = 0.5189), readmission rate (12% versus 15%, p = 0.6022) or length of hospital stay (8 (7-11) versus 10 (8-17) days, p = 0.0652). There was no 30-day mortality after enucleation compared to 1.6% (n = 1) after formal resection. 10-year overall survival (OS) and disease-free survival (DFS) was similar between the two groups (OS: 89% versus 77%, p = 0.2756; DFS: 98% versus 91%, p = 0.0873). Enucleation presents a safe surgical approach for well-differentiated nf-pNEN with good long-term outcomes for selected patients. | ||
| 650 | 4 | |a enucleation | |
| 650 | 4 | |a formal resection | |
| 650 | 4 | |a neuroendocrine tumors | |
| 650 | 4 | |a pNEN | |
| 650 | 4 | |a surgery | |
| 700 | 1 | |a Bechtiger, Fabiola A. |e VerfasserIn |0 (DE-588)1260698335 |0 (DE-627)1807580644 |4 aut | |
| 700 | 1 | |a Hinz, Ulf |e VerfasserIn |0 (DE-588)1022150499 |0 (DE-627)716927748 |0 (DE-576)175505284 |4 aut | |
| 700 | 1 | |a Lewosinska, Magdalena |d 1989- |e VerfasserIn |0 (DE-588)1206953225 |0 (DE-627)169318947X |4 aut | |
| 700 | 1 | |a Billmann, Franck |d 1977- |e VerfasserIn |0 (DE-588)13744902X |0 (DE-627)695823655 |0 (DE-576)303567651 |4 aut | |
| 700 | 1 | |a Hackert, Thilo |d 1971- |e VerfasserIn |0 (DE-588)122158512 |0 (DE-627)70579346X |0 (DE-576)182659208 |4 aut | |
| 700 | 1 | |a Büchler, Markus W. |d 1955- |e VerfasserIn |0 (DE-588)120893339 |0 (DE-627)080952526 |0 (DE-576)292434146 |4 aut | |
| 700 | 1 | |a Schimmack, Simon |d 1978- |e VerfasserIn |0 (DE-588)133380319 |0 (DE-627)544036662 |0 (DE-576)299808459 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 14(2022), 10, special issue, Artikel-ID 2570, Seite 1-12 |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a Enucleation is a feasible procedure for well-differentiated pNEN a matched pair analysis |
| 773 | 1 | 8 | |g volume:14 |g year:2022 |g number:10 |g supplement:special issue |g elocationid:2570 |g pages:1-12 |g extent:12 |a Enucleation is a feasible procedure for well-differentiated pNEN a matched pair analysis |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers14102570 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/14/10/2570 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220623 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 133380319 |a Schimmack, Simon |m 133380319:Schimmack, Simon |d 910000 |d 910200 |e 910000PS133380319 |e 910200PS133380319 |k 0/910000/ |k 1/910000/910200/ |p 8 |y j | ||
| 998 | |g 120893339 |a Büchler, Markus W. |m 120893339:Büchler, Markus W. |d 910000 |d 910200 |e 910000PB120893339 |e 910200PB120893339 |k 0/910000/ |k 1/910000/910200/ |p 7 | ||
| 998 | |g 122158512 |a Hackert, Thilo |m 122158512:Hackert, Thilo |d 910000 |d 910200 |d 50000 |e 910000PH122158512 |e 910200PH122158512 |e 50000PH122158512 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 6 | ||
| 998 | |g 13744902X |a Billmann, Franck |m 13744902X:Billmann, Franck |d 910000 |d 910200 |e 910000PB13744902X |e 910200PB13744902X |k 0/910000/ |k 1/910000/910200/ |p 5 | ||
| 998 | |g 1206953225 |a Lewosinska, Magdalena |m 1206953225:Lewosinska, Magdalena |d 910000 |d 910200 |e 910000PL1206953225 |e 910200PL1206953225 |k 0/910000/ |k 1/910000/910200/ |p 4 | ||
| 998 | |g 1022150499 |a Hinz, Ulf |m 1022150499:Hinz, Ulf |d 910000 |d 910200 |e 910000PH1022150499 |e 910200PH1022150499 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 1260698335 |a Bechtiger, Fabiola A. |m 1260698335:Bechtiger, Fabiola A. |d 910000 |d 910200 |e 910000PB1260698335 |e 910200PB1260698335 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 1101590475 |a Nießen, Anna |m 1101590475:Nießen, Anna |d 910000 |d 910200 |e 910000PN1101590475 |e 910200PN1101590475 |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1807581489 |e 4155348101 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"23 May 2022"}],"relHost":[{"title":[{"title_sort":"Cancers","title":"Cancers"}],"id":{"eki":["614095670"],"zdb":["2527080-1"],"issn":["2072-6694"]},"note":["Gesehen am 27.05.2020"],"disp":"Enucleation is a feasible procedure for well-differentiated pNEN a matched pair analysisCancers","part":{"pages":"1-12","extent":"12","year":"2022","volume":"14","issue":"10","text":"14(2022), 10, special issue, Artikel-ID 2570, Seite 1-12"},"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisher":"MDPI","publisherPlace":"Basel","dateIssuedKey":"2009","dateIssuedDisp":"2009-"}],"pubHistory":["1.2009 -"],"recId":"614095670"}],"name":{"displayForm":["Anna Nießen, Fabiola A. Bechtiger, Ulf Hinz, Magdalena Lewosinska, Franck Billmann, Thilo Hackert, Markus W. Büchler and Simon Schimmack"]},"person":[{"family":"Nießen","roleDisplay":"VerfasserIn","given":"Anna","role":"aut","display":"Nießen, Anna"},{"roleDisplay":"VerfasserIn","family":"Bechtiger","given":"Fabiola A.","role":"aut","display":"Bechtiger, Fabiola A."},{"display":"Hinz, Ulf","role":"aut","given":"Ulf","roleDisplay":"VerfasserIn","family":"Hinz"},{"role":"aut","display":"Lewosinska, Magdalena","given":"Magdalena","family":"Lewosinska","roleDisplay":"VerfasserIn"},{"display":"Billmann, Franck","role":"aut","given":"Franck","family":"Billmann","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Hackert","given":"Thilo","display":"Hackert, Thilo","role":"aut"},{"role":"aut","display":"Büchler, Markus W.","given":"Markus W.","family":"Büchler","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Schimmack","display":"Schimmack, Simon","role":"aut","given":"Simon"}],"physDesc":[{"extent":"12 S."}],"note":["Gesehen am 23.06.2022","This article belongs to the special issue \"Updates on diagnostic and therapeutic management of neuroendocrine neoplasms\""],"id":{"doi":["10.3390/cancers14102570"],"eki":["1807581489"]},"title":[{"subtitle":"a matched pair analysis","title_sort":"Enucleation is a feasible procedure for well-differentiated pNEN","title":"Enucleation is a feasible procedure for well-differentiated pNEN"}],"recId":"1807581489"} | ||
| SRT | |a NIESSENANNENUCLEATIO2320 | ||