Modular approach for modeling cell motility
Modeling cell movement is a challenging task since the motility machinery is highly complex. Moreover, there is a rather broad diversity of different cell types. In order to obtain insights into generic features of the motility mechanisms of several distinct cell types, we propose a modular approach...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 June 2014
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| In: |
European physical journal special topics
Year: 2014, Volume: 223, Issue: 7, Pages: 1265-1277 |
| ISSN: | 1951-6401 |
| DOI: | 10.1140/epjst/e2014-02190-2 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1140/epjst/e2014-02190-2
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| Author Notes: | F. Ziebert and I.S. Aranson |
| Summary: | Modeling cell movement is a challenging task since the motility machinery is highly complex. Moreover, there is a rather broad diversity of different cell types. In order to obtain insights into generic features of the motility mechanisms of several distinct cell types, we propose a modular approach that starts with a minimal model, consisting of a phase field description of the moving cell boundary and a simplified internal dynamics. We discuss how this starting point can be extended to increase the level of detail, and how the internal dynamics “module” can be changed/adjusted to properly model various cell types. The former route allows studying specific processes involved in cell motility in the framework of a self-organized moving domain, and the latter might permit to put different cellular motility mechanisms into a unified framework. |
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| Item Description: | Gesehen am 27.09.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1951-6401 |
| DOI: | 10.1140/epjst/e2014-02190-2 |