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Biphasic effects of blue light irradiation on human umbilical vein endothelial cells

Blue light regulates biological function in various cells, such as proliferation, oxidative stress, and cell death. We employed blue light illumination on human umbilical vein endothelial cells utilizing a LED device at 453 nm wavelength and revealed a novel biphasic response on human umbilical vein...

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Main Authors: Kan, Kejia (Author) , Mu, Yifei (Author) , Bouschbacher, Marielle (Author) , Sticht, Carsten (Author) , Kuch, Natalia (Author) , Sigl, Martin (Author) , Rahbari, Nuh Nabi (Author) , Gretz, Norbert (Author) , Pallavi, Prama (Author) , Keese, Michael (Author)
Format: Article (Journal)
Language:English
Published: 16 July 2021
In: Biomedicines
Year: 2021, Volume: 9, Issue: 7, Pages: 1-16
ISSN:2227-9059
DOI:10.3390/biomedicines9070829
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/biomedicines9070829
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2227-9059/9/7/829
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Author Notes:Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi and Michael Keese
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Summary:Blue light regulates biological function in various cells, such as proliferation, oxidative stress, and cell death. We employed blue light illumination on human umbilical vein endothelial cells utilizing a LED device at 453 nm wavelength and revealed a novel biphasic response on human umbilical vein endothelial cells (HUVECs). The results showed that low fluence blue light irradiation promoted the fundamental cell activities, including cell viability, migration and angiogenesis by activating the angiogenic pathways such as the VEGF signaling pathway. In contrast, high fluence illumination caused the opposite effect on those activities by upregulating pro-apoptotic signaling cascades like ferroptosis, necroptosis and the p53 signaling pathways. Our results provide an underlying insight into photobiomodulation by blue light and may help to implement potential treatment strategies for treating angiogenesis-dependent diseases.
Item Description:Published: 16 July 2021
Gesehen am 24.06.2022
Physical Description:Online Resource
ISSN:2227-9059
DOI:10.3390/biomedicines9070829

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