p24 proteins are required for secretion of Wnt ligands
During development and disease, the exocytosis of signalling molecules, such as Wnt ligands, is essential to orchestrate cellular programs in multicellular organisms. However, it remains a largely unresolved question whether signalling molecules follow specialized transport routes through the exocyt...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 November 2011
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| In: |
EMBO reports
Year: 2011, Volume: 12, Issue: 12, Pages: 1265-1272 |
| ISSN: | 1469-3178 |
| DOI: | 10.1038/embor.2011.212 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/embor.2011.212 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.1038/embor.2011.212 
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| Author Notes: | Tina Buechling, Varun Chaudhary, Kerstin Spirohn, Matthias Weiss & Michael Boutros |
| Summary: | During development and disease, the exocytosis of signalling molecules, such as Wnt ligands, is essential to orchestrate cellular programs in multicellular organisms. However, it remains a largely unresolved question whether signalling molecules follow specialized transport routes through the exocytic pathway. Here we identify several Drosophila p24 proteins that are required for Wnt signalling. We demonstrate that one of these p24 proteins, namely Opossum, shuttles in the early secretory pathway, and that the Drosophila Wnt proteins are retained in the absence of p24 proteins. Our results indicate that Wnt secretion relies on a specialized anterograde secretion route with p24 proteins functioning as conserved cargo receptors. |
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| Item Description: | Gesehen am 24.06.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1469-3178 |
| DOI: | 10.1038/embor.2011.212 |