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α1-adrenoceptors and takotsubo syndrome: pathophysiologic connotations : authors’ reply

We appreciate the interest of Dr Madias in our paper entitled ‘Alpha 1 adrenoceptor signaling contributes to toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes’.1We agree with Dr Madias about the illustrated points.2 Regarding recept...

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Bibliographic Details
Main Authors: Huang, Mengying (Author) , El-Battrawy, Ibrahim (Author) , Zhou, Xiao-Bo (Author) , Akın, Ibrahim (Author)
Format: Article (Journal) Editorial
Language:English
Published: July 2021
In: Europace
Year: 2021, Volume: 23, Issue: 7, Pages: 1152
ISSN:1532-2092
DOI:10.1093/europace/euab120
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/europace/euab120
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Author Notes:Mengying Huang, Ibrahim El-Battrawy, Xiaobo Zhou, Ibrahim Akin
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Summary:We appreciate the interest of Dr Madias in our paper entitled ‘Alpha 1 adrenoceptor signaling contributes to toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes’.1We agree with Dr Madias about the illustrated points.2 Regarding receptors involved in takotsubo syndrome (TTS), we also believe that beta- and alpha-adrenoceptors must play some role in the pathogenesis of TTS. The role and mechanisms of beta-receptor activation in the toxic effect of catecholamine excess have been investigated in numerous studies using various models, including human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The contribution of beta-adrenoceptors to TTS has been well established. Although alpha-receptors in cardiomyocytes have a lower density than beta-receptors, they can also possibly contribute to TTS to a certain extent. Our paper only attempts to emphasize the role of alpha receptors in this scenario and does not underscore the importance of beta-receptors in TTS.
Item Description:Im Titel ist die "1" bei "α1-adrenoceptors" tiefgestellt
Gesehen am 28.06.2022
Physical Description:Online Resource
ISSN:1532-2092
DOI:10.1093/europace/euab120

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