α1-adrenoceptors and takotsubo syndrome: pathophysiologic connotations : authors’ reply
We appreciate the interest of Dr Madias in our paper entitled ‘Alpha 1 adrenoceptor signaling contributes to toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes’.1We agree with Dr Madias about the illustrated points.2 Regarding recept...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2021
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| In: |
Europace
Year: 2021, Jahrgang: 23, Heft: 7, Pages: 1152 |
| ISSN: | 1532-2092 |
| DOI: | 10.1093/europace/euab120 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/europace/euab120
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| Verfasserangaben: | Mengying Huang, Ibrahim El-Battrawy, Xiaobo Zhou, Ibrahim Akin |
| Zusammenfassung: | We appreciate the interest of Dr Madias in our paper entitled ‘Alpha 1 adrenoceptor signaling contributes to toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes’.1We agree with Dr Madias about the illustrated points.2 Regarding receptors involved in takotsubo syndrome (TTS), we also believe that beta- and alpha-adrenoceptors must play some role in the pathogenesis of TTS. The role and mechanisms of beta-receptor activation in the toxic effect of catecholamine excess have been investigated in numerous studies using various models, including human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The contribution of beta-adrenoceptors to TTS has been well established. Although alpha-receptors in cardiomyocytes have a lower density than beta-receptors, they can also possibly contribute to TTS to a certain extent. Our paper only attempts to emphasize the role of alpha receptors in this scenario and does not underscore the importance of beta-receptors in TTS. |
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| Beschreibung: | Im Titel ist die "1" bei "α1-adrenoceptors" tiefgestellt Gesehen am 28.06.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1532-2092 |
| DOI: | 10.1093/europace/euab120 |