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Human immunodeficiency virus associated tuberculosis more often due to recent infection than reactivation of latent infection [Review article]

BACKGROUND: It is unclear whether human immunodeficiency virus (HIV) increases the risk of tuberculosis (TB) mainly through reactivation or following recent Mycobacterium tuberculosis (re)infection. Within a DNA fingerprint-defined cluster of TB cases, reactivation cases are assumed to be the source...

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Hauptverfasser: Houben, Rein M. G. J. (VerfasserIn) , Crampin, A. C. (VerfasserIn) , Ndhlovu, R. (VerfasserIn) , Sonnenberg, P. (VerfasserIn) , Godfrey-Faussett, P. (VerfasserIn) , Haas, W. H. (VerfasserIn) , Engelmann, Guido (VerfasserIn) , Lombard, C. J. (VerfasserIn) , Wilkinson, D. (VerfasserIn) , Bruchfeld, J. (VerfasserIn) , Lockman, S. (VerfasserIn) , Tappero, J. (VerfasserIn) , Glynn, J.R. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: January 2011
In: The international journal of tuberculosis and lung disease
Year: 2011, Jahrgang: 15, Heft: 1, Pages: 24-31
ISSN:1815-7920
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://www.ingentaconnect.com/contentone/iuatld/ijtld/2011/00000015/00000001/art00006#
Volltext
Verfasserangaben:R.M.G.J. Houben, A.C. Crampin, R. Ndhlovu, P. Sonnenberg, P. Godfrey-Faussett, W.H. Haas, G. Engelmann, C.J. Lombard, D. Wilkinson, J. Bruchfeld, S. Lockman, J. Tappero, J.R. Glynn
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Zusammenfassung:BACKGROUND: It is unclear whether human immunodeficiency virus (HIV) increases the risk of tuberculosis (TB) mainly through reactivation or following recent Mycobacterium tuberculosis (re)infection. Within a DNA fingerprint-defined cluster of TB cases, reactivation cases are assumed to be the source of infection for subsequent secondary cases. As HIV-positive TB cases are less likely to be source cases, equal or higher clustering in HIV-positives would suggest that HIV mainly increases the risk of TB following recent infection.METHODS: A systematic review was conducted to identify all studies on TB clustering and HIV infection in HIV-endemic populations. Available individual patient data from eligible studies were pooled to analyse the association between clustering and HIV.RESULTS: Of seven eligible studies, six contributed individual patient data on 2116 patients. Clustering was as, or more, likely in the HIV-positive population, both overall (summary OR 1.26, 95%CI 1.0-1.5), and within age groups (OR 1.50, 95%CI 0.9-2.3; OR 1.00, 95%CI 0.8-1.3 and OR 2.57, 95%CI 1.4-5.7) for ages 15-25, 26-50 and >50 years, respectively.CONCLUSIONS: Our results suggest that HIV infection mainly increases the risk of TB following recent M. tuberculosis transmission, and that TB control measures in HIV-endemic settings should therefore focus on controlling M. tuberculosis transmission rather than treating individuals with latent M. tuberculosis infection.
Beschreibung:Gesehen am 30.06.2022
Beschreibung:Online Resource
ISSN:1815-7920

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