Idiopathic myelofibrosis with extramedullary hematopoiesis in the kidneys
Extramedullary hematopoiesis is a common finding in idiopathic myelofibrosis and is usually found in liver and spleen. We report on a patient with biopsy-proven myeloid metaplasia and fibrosis of the renal parenchyma as a rare cause of chronic renal failure. The renal biopsy specimen showed numerous...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1999
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| In: |
Clinical nephrology
Year: 1999, Jahrgang: 52, Heft: 4, Pages: 256-262 |
| ISSN: | 0301-0430 |
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| Verfasserangaben: | P. Schnuelle, R. Waldherr, K.J. Lehmann, J. Woenckhaus, W. Back, Z. Niemir, F. J. van der Woude |
| Zusammenfassung: | Extramedullary hematopoiesis is a common finding in idiopathic myelofibrosis and is usually found in liver and spleen. We report on a patient with biopsy-proven myeloid metaplasia and fibrosis of the renal parenchyma as a rare cause of chronic renal failure. The renal biopsy specimen showed numerous infiltrates of hematopoietic cells expressing growth factors like M-CSF, GM-CSF, IL-1beta and PDGF while TGF-beta was not elevated. These findings suggest that hematopoietic growth factors play a key role in the pathogenesis of this condition causing proliferating fibrosis and enlargement of the kidneys. |
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| ISSN: | 0301-0430 |