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Idiopathic myelofibrosis with extramedullary hematopoiesis in the kidneys

Extramedullary hematopoiesis is a common finding in idiopathic myelofibrosis and is usually found in liver and spleen. We report on a patient with biopsy-proven myeloid metaplasia and fibrosis of the renal parenchyma as a rare cause of chronic renal failure. The renal biopsy specimen showed numerous...

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Hauptverfasser: Schnülle, Peter (VerfasserIn) , Waldherr, Rüdiger (VerfasserIn) , Lehmann, Karl-Jürgen (VerfasserIn) , Woenckhaus, J. (VerfasserIn) , Back, Walter (VerfasserIn) , Niemir, Z. (VerfasserIn) , Woude, Fokko J. van der (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1999
In: Clinical nephrology
Year: 1999, Jahrgang: 52, Heft: 4, Pages: 256-262
ISSN:0301-0430
Online-Zugang: Volltext
Verfasserangaben:P. Schnuelle, R. Waldherr, K.J. Lehmann, J. Woenckhaus, W. Back, Z. Niemir, F. J. van der Woude

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520 |a Extramedullary hematopoiesis is a common finding in idiopathic myelofibrosis and is usually found in liver and spleen. We report on a patient with biopsy-proven myeloid metaplasia and fibrosis of the renal parenchyma as a rare cause of chronic renal failure. The renal biopsy specimen showed numerous infiltrates of hematopoietic cells expressing growth factors like M-CSF, GM-CSF, IL-1beta and PDGF while TGF-beta was not elevated. These findings suggest that hematopoietic growth factors play a key role in the pathogenesis of this condition causing proliferating fibrosis and enlargement of the kidneys. 
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