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Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy

Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the lack of stand...

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Hauptverfasser: Hundeshagen, Phillip (VerfasserIn) , Hamacher-Brady, Anne (VerfasserIn) , Eils, Roland (VerfasserIn) , Brady, Nathan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 02 June 2011
In: BMC biology
Year: 2011, Jahrgang: 9, Pages: 1-15
ISSN:1741-7007
DOI:10.1186/1741-7007-9-38
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1741-7007-9-38
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Verfasserangaben:Phillip Hundeshagen, Anne Hamacher-Brady, Roland Eils and Nathan R. Brady
Beschreibung
Zusammenfassung:Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the lack of standardized assays capable of precisely reporting autophagic activity.
Beschreibung:Gesehen am 01.07.2022
Beschreibung:Online Resource
ISSN:1741-7007
DOI:10.1186/1741-7007-9-38

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