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Cerebrospinal fluid concentrations of meropenem and vancomycin in ventriculitis patients obtained by TDM-guided continuous infusion

Effective antibiotic therapy of cerebral infections such as meningitis or ventriculitis is hindered by low penetration into the cerebrospinal fluid (CSF). Because continuous infusion of meropenem and vancomycin and routine therapeutic drug monitoring (TDM) have been proposed to optimize antimicrobia...

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Main Authors: Tiede, Christoph (Author) , Chiriac, Ute (Author) , Dubinski, Daniel (Author) , Raimann, Florian J. (Author) , Frey, Otto R. (Author) , Röhr, Anka C. (Author) , Wieduwilt, Anna (Author) , Eibach, Michael (Author) , Filmann, Natalie (Author) , Senft, Christian (Author) , Zacharowski, Kai (Author) , Seifert, Volker (Author) , Mersmann, Jan (Author)
Format: Article (Journal)
Language:English
Published: 20 November 2021
In: Antibiotics
Year: 2021, Volume: 10, Issue: 11, Pages: 1-11
ISSN:2079-6382
DOI:10.3390/antibiotics10111421
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/antibiotics10111421
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2079-6382/10/11/1421
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Author Notes:Christoph Tiede, Ute Chiriac, Daniel Dubinski, Florian J. Raimann, Otto R. Frey, Anka C. Röhr, Anna Wieduwilt, Michael Eibach, Natalie Filmann, Christian Senft, Kai Zacharowski, Volker Seifert and Jan Mersmann
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Summary:Effective antibiotic therapy of cerebral infections such as meningitis or ventriculitis is hindered by low penetration into the cerebrospinal fluid (CSF). Because continuous infusion of meropenem and vancomycin and routine therapeutic drug monitoring (TDM) have been proposed to optimize antimicrobial exposure in ventriculitis patients, an individualized dosing strategy was implemented in our department. We present a retrospective analysis of meropenem and vancomycin concentrations in serum and CSF in the first nine ventriculitis patients treated with continuous infusion and TDM-guided dose optimization aiming at 20-30 mg/L. Median initial dosing was 8.8 g/24 h meropenem and 4.25 g/24 h vancomycin, respectively, resulting in median serum concentrations of 21.3 mg/L for meropenem and 24.5 mg/L for vancomycin and CSF concentrations of 3.4 mg/L for meropenem and 1.7 mg/L for vancomycin. Median CSF penetration was 15% for meropenem and 7% for vancomycin. With initial dosing, all but one patient achieved CSF concentrations above 1 mg/L. Dose adjustment according to TDM ensured sufficient CSF concentrations in all patients within 48 h of treatment. Given the limited penetration, continuous infusion of meropenem and vancomycin based on renal function and TDM-guided dose optimization appears a reasonable approach to attain sufficient CSF concentrations in ventriculitis patients.
Item Description:Gesehen am 01.07.2022
This article belongs to the Special Issue TDM, Individual Dosing and Application of Antibiotics/Antiinfectives in Critically Ill Patients
Physical Description:Online Resource
ISSN:2079-6382
DOI:10.3390/antibiotics10111421

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