Comparison study of myocardial radiomics feature properties on energy-integrating and photon-counting detector CT
The implementation of radiomics-based, quantitative imaging parameters is hampered by a lack of stability and standardization. Photon-counting computed tomography (PCCT), compared to energy-integrating computed tomography (EICT), does rely on a novel detector technology, promising better spatial res...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2022
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| In: |
Diagnostics
Year: 2022, Volume: 12, Issue: 5, Pages: 1-11 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics12051294 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/diagnostics12051294 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2075-4418/12/5/1294 
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| Author Notes: | Isabelle Ayx, Hishan Tharmaseelan, Alexander Hertel, Dominik Nörenberg, Daniel Overhoff, Lukas T. Rotkopf, Philipp Riffel, Stefan O. Schoenberg and Matthias F. Froelich |
| Summary: | The implementation of radiomics-based, quantitative imaging parameters is hampered by a lack of stability and standardization. Photon-counting computed tomography (PCCT), compared to energy-integrating computed tomography (EICT), does rely on a novel detector technology, promising better spatial resolution and contrast-to-noise ratio. However, its effect on radiomics feature properties is unknown. This work investigates this topic in myocardial imaging. In this retrospective, single-center IRB-approved study, the left ventricular myocardium was segmented on CT, and the radiomics features were extracted using pyradiomics. To compare features between scanners, a t-test for non-paired samples and F-test was performed, with a threshold of 0.05 set as a benchmark for significance. Feature correlations were calculated by the Pearson correlation coefficient, and visualization was performed with heatmaps. A total of 50 patients (56% male, mean age 56) were enrolled in this study, with equal proportions of PCCT and EICT. First-order features were, nearly, comparable between both groups. However, higher-order features showed a partially significant difference between PCCT and EICT. While first-order radiomics features of left ventricular myocardium show comparability between PCCT and EICT, detected differences of higher-order features may indicate a possible impact of improved spatial resolution, better detection of lower-energy photons, and a better signal-to-noise ratio on texture analysis on PCCT. |
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| Item Description: | Published: 23 May 2022 Gesehen am 01.07.2022 |
| Physical Description: | Online Resource |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics12051294 |