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Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease

Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration. T-tau levels, however, can be increased in very early disease stages, when neurodegeneration is limited, and can be normal in advanced dise...

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Main Authors: Visser, Pieter Jelle (Author) , Reus, Lianne M. (Author) , Gobom, Johan (Author) , Kerkmeijer-Jansen, Iris E. (Author) , Dicks, Ellen (Author) , van der Lee, Sven J. (Author) , Tsolaki, Magda (Author) , Verhey, Frans R. J. (Author) , Popp, Julius (Author) , Martinez-Lage, Pablo (Author) , Vandenberghe, Rik (Author) , Lleó, Alberto (Author) , Molinuevo, José Luís (Author) , Engelborghs, Sebastiaan (Author) , Freund-Levi, Yvonne (Author) , Frölich, Lutz (Author) , Sleegers, Kristel (Author) , Dobricic, Valerija (Author) , Lovestone, Simon (Author) , Streffer, Johannes (Author) , Vos, Stephanie J. B. (Author) , Bos, Isabelle (Author) , Smit, August B. (Author) , Blennow, Kaj (Author) , Scheltens, Philip (Author) , Teunissen, Charlotte E. (Author) , Bertram, Lars (Author) , Zetterberg, Henrik (Author) , Tijms, Betty M. (Author)
Format: Article (Journal)
Language:English
Published: 28 March 2022
In: Molecular neurodegeneration
Year: 2022, Volume: 17, Pages: 1-16
ISSN:1750-1326
DOI:10.1186/s13024-022-00521-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13024-022-00521-3
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Author Notes:Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R.J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J.B. Vos, Isabelle Bos, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg and Betty M. Tijms
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Summary:Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration. T-tau levels, however, can be increased in very early disease stages, when neurodegeneration is limited, and can be normal in advanced disease stages. This suggests that t-tau levels may be driven by other mechanisms as well. Because tau pathophysiology is emerging as treatment target for AD, we aimed to clarify molecular processes associated with CSF t-tau levels.
Item Description:Gesehen am 02.07.2022
Physical Description:Online Resource
ISSN:1750-1326
DOI:10.1186/s13024-022-00521-3

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