Novel roles for hERG K+ channels in cell proliferation and apoptosis
The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K+ channels are als...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 August 2011
|
| In: |
Cell death & disease
Year: 2011, Volume: 2, Issue: 8, Pages: 1-8 |
| ISSN: | 2041-4889 |
| DOI: | 10.1038/cddis.2011.77 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/cddis.2011.77 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/cddis201177 
|
| Author Notes: | J. Jehle, P.A. Schweizer, H.A. Katus and D. Thomas |
| Summary: | The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K+ channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K+ channels as future drug target in anticancer therapy is highlighted. |
|---|---|
| Item Description: | Gesehen am 05.07.2022 Im Titel ist das Pluszeichen hochgestellt |
| Physical Description: | Online Resource |
| ISSN: | 2041-4889 |
| DOI: | 10.1038/cddis.2011.77 |