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Mouse granzyme K has pro-inflammatory potential

Granzymes (gzms) are key components of T-killer (Tc) cells believed to mediate pro-apoptotic activities. Recent evidence suggests that gzms also possess non-cytotoxic activities that contribute to host defense. In this study, we show that Tc cells from lymphocytic choriomeningitis virus (LCMV)-infec...

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Bibliographic Details
Main Authors: Jöckel, Lars Thomas (Author) , Wallich, Reinhard (Author) , Martin, P. (Author) , Sanchez-Martinez, D. (Author) , Weber, F. C. (Author) , Martin, S. F. (Author) , Borner, C. (Author) , Pardo, J. (Author) , Froelich, C. (Author) , Simon, M. M. (Author)
Format: Article (Journal)
Language:English
Published: 11 February 2011
In: Cell death and differentiation
Year: 2011, Volume: 18, Issue: 7, Pages: 1112-1119
ISSN:1476-5403
DOI:10.1038/cdd.2011.5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/cdd.2011.5
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/cdd20115
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Author Notes:L.T. Joeckel, R. Wallich, P. Martin, D. Sanchez-Martinez, F.C. Weber, S.F. Martin, C. Borner, J. Pardo, C. Froelich and M.M. Simon
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Summary:Granzymes (gzms) are key components of T-killer (Tc) cells believed to mediate pro-apoptotic activities. Recent evidence suggests that gzms also possess non-cytotoxic activities that contribute to host defense. In this study, we show that Tc cells from lymphocytic choriomeningitis virus (LCMV)-infected wild-type (wt) and gzm A/B-deficient mice express similar levels of gzmK protein, with both mouse strains efficiently controlling infection. GzmK, in recombinant form or secreted by ex vivo-derived LCMV-immune gzmAxB−/− Tc cells, lacks pro-apoptotic activity. Instead, gzmK induces primary mouse macrophages to process and secrete interleukin-1β, independent of the ATP receptor P2X7. Together with the finding that IL-1Ra (Anakinra) treatment inhibits virus elimination but not generation of cytotoxic Tc cells in wt mice, the data suggest that Tc cells control LCMV through non-cytotoxic processes that involve gzmK.
Item Description:Gesehen am 05.07.2022
Physical Description:Online Resource
ISSN:1476-5403
DOI:10.1038/cdd.2011.5

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