Mouse granzyme K has pro-inflammatory potential
Granzymes (gzms) are key components of T-killer (Tc) cells believed to mediate pro-apoptotic activities. Recent evidence suggests that gzms also possess non-cytotoxic activities that contribute to host defense. In this study, we show that Tc cells from lymphocytic choriomeningitis virus (LCMV)-infec...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 February 2011
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| In: |
Cell death and differentiation
Year: 2011, Jahrgang: 18, Heft: 7, Pages: 1112-1119 |
| ISSN: | 1476-5403 |
| DOI: | 10.1038/cdd.2011.5 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/cdd.2011.5 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/cdd20115 
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| Verfasserangaben: | L.T. Joeckel, R. Wallich, P. Martin, D. Sanchez-Martinez, F.C. Weber, S.F. Martin, C. Borner, J. Pardo, C. Froelich and M.M. Simon |
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| 245 | 1 | 0 | |a Mouse granzyme K has pro-inflammatory potential |c L.T. Joeckel, R. Wallich, P. Martin, D. Sanchez-Martinez, F.C. Weber, S.F. Martin, C. Borner, J. Pardo, C. Froelich and M.M. Simon |
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| 520 | |a Granzymes (gzms) are key components of T-killer (Tc) cells believed to mediate pro-apoptotic activities. Recent evidence suggests that gzms also possess non-cytotoxic activities that contribute to host defense. In this study, we show that Tc cells from lymphocytic choriomeningitis virus (LCMV)-infected wild-type (wt) and gzm A/B-deficient mice express similar levels of gzmK protein, with both mouse strains efficiently controlling infection. GzmK, in recombinant form or secreted by ex vivo-derived LCMV-immune gzmAxB−/− Tc cells, lacks pro-apoptotic activity. Instead, gzmK induces primary mouse macrophages to process and secrete interleukin-1β, independent of the ATP receptor P2X7. Together with the finding that IL-1Ra (Anakinra) treatment inhibits virus elimination but not generation of cytotoxic Tc cells in wt mice, the data suggest that Tc cells control LCMV through non-cytotoxic processes that involve gzmK. | ||
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| 650 | 4 | |a Enzymes | |
| 650 | 4 | |a Viral infection | |
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| 700 | 1 | |a Simon, M. M. |e VerfasserIn |4 aut | |
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