Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation
The early steps of differentiation of human B cells into plasma cells are poorly known. We report a transitional population of CD20low/−CD38− preplasmablasts along differentiation of human memory B cells into plasma cells in vitro. Preplasmablasts lack documented B cell or plasma cell (CD20, CD38, a...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 3, 2011
|
| In: |
The journal of immunology
Year: 2011, Volume: 187, Issue: 8, Pages: 3931-3941 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.1101230 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.1101230 Verlag, lizenzpflichtig, Volltext: https://www.jimmunol.org/content/187/8/3931 
|
| Author Notes: | Michel Jourdan, Anouk Caraux, Gersende Caron, Nicolas Robert, Geneviève Fiol, Thierry Rème, Karine Bolloré, Jean-Pierre Vendrell, Simon Le Gallou, Frédéric Mourcin, John De Vos, Alboukadel Kassambara, Christophe Duperray, Dirk Hose, Thierry Fest, Karin Tarte, and Bernard Klein |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1809160626 | ||
| 003 | DE-627 | ||
| 005 | 20220820213854.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220705s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4049/jimmunol.1101230 |2 doi | |
| 035 | |a (DE-627)1809160626 | ||
| 035 | |a (DE-599)KXP1809160626 | ||
| 035 | |a (OCoLC)1341463314 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Jourdan, Michel |e VerfasserIn |0 (DE-588)1078702489 |0 (DE-627)839163606 |0 (DE-576)451630076 |4 aut | |
| 245 | 1 | 0 | |a Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation |c Michel Jourdan, Anouk Caraux, Gersende Caron, Nicolas Robert, Geneviève Fiol, Thierry Rème, Karine Bolloré, Jean-Pierre Vendrell, Simon Le Gallou, Frédéric Mourcin, John De Vos, Alboukadel Kassambara, Christophe Duperray, Dirk Hose, Thierry Fest, Karin Tarte, and Bernard Klein |
| 264 | 1 | |c October 3, 2011 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.07.2022 | ||
| 520 | |a The early steps of differentiation of human B cells into plasma cells are poorly known. We report a transitional population of CD20low/−CD38− preplasmablasts along differentiation of human memory B cells into plasma cells in vitro. Preplasmablasts lack documented B cell or plasma cell (CD20, CD38, and CD138) markers, express CD30 and IL-6R, and secrete Igs at a weaker level than do plasmablasts or plasma cells. These preplasmablasts further differentiate into CD20−CD38highCD138− plasmablasts and then CD20−CD38highCD138+ plasma cells. Preplasmablasts were fully characterized in terms of whole genome transcriptome profiling and phenotype. Preplasmablasts coexpress B and plasma cell transcription factors, but at a reduced level compared with B cells, plasmablasts, or plasma cells. They express the unspliced form of XBP1 mRNA mainly, whereas plasmablasts and plasma cells express essentially the spliced form. An in vivo counterpart (CD19+CD20low/−CD38−IL-6R+ cells) of in vitro-generated preplasmablasts could be detected in human lymph nodes (0.06% of CD19+ cells) and tonsils (0.05% of CD19+ cells). An open access “B to Plasma Cell Atlas,” which makes it possible to interrogate gene expression in the process of B cell to plasma cell differentiation, is provided. Taken together, our findings show the existence of a transitional preplasmablast population using an in vitro model of plasma cell generation and of its in vivo counterpart in various lymphoid tissues. | ||
| 700 | 1 | |a Caraux, Anouk |e VerfasserIn |4 aut | |
| 700 | 1 | |a Caron, Gersende |e VerfasserIn |4 aut | |
| 700 | 1 | |a Robert, Nicolas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fiol, Geneviève |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rème, Thierry |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bolloré, Karine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vendrell, Jean-Pierre |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gallou, Simon Le |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mourcin, Frédéric |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vos, John De |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kassambara, Alboukadel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Duperray, Christophe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hose, Dirk |d 1969- |e VerfasserIn |0 (DE-588)139824995 |0 (DE-627)613790308 |0 (DE-576)313431698 |4 aut | |
| 700 | 1 | |a Fest, Thierry |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tarte, Karin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klein, Bernard |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of immunology |d Rockville, Md. : American Association of Immunologists, 1916 |g 187(2011), 8, Seite 3931-3941 |h Online-Ressource |w (DE-627)269535217 |w (DE-600)1475085-5 |w (DE-576)079963838 |x 1550-6606 |7 nnas |a Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation |
| 773 | 1 | 8 | |g volume:187 |g year:2011 |g number:8 |g pages:3931-3941 |g extent:11 |a Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation |
| 856 | 4 | 0 | |u https://doi.org/10.4049/jimmunol.1101230 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.jimmunol.org/content/187/8/3931 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220705 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 139824995 |a Hose, Dirk |m 139824995:Hose, Dirk |d 910000 |d 910100 |e 910000PH139824995 |e 910100PH139824995 |k 0/910000/ |k 1/910000/910100/ |p 14 | ||
| 999 | |a KXP-PPN1809160626 |e 4161416903 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","given":"Michel","display":"Jourdan, Michel","family":"Jourdan"},{"display":"Caraux, Anouk","given":"Anouk","role":"aut","family":"Caraux"},{"display":"Caron, Gersende","role":"aut","given":"Gersende","family":"Caron"},{"display":"Robert, Nicolas","given":"Nicolas","role":"aut","family":"Robert"},{"family":"Fiol","display":"Fiol, Geneviève","given":"Geneviève","role":"aut"},{"family":"Rème","given":"Thierry","role":"aut","display":"Rème, Thierry"},{"family":"Bolloré","display":"Bolloré, Karine","role":"aut","given":"Karine"},{"family":"Vendrell","given":"Jean-Pierre","role":"aut","display":"Vendrell, Jean-Pierre"},{"family":"Gallou","display":"Gallou, Simon Le","given":"Simon Le","role":"aut"},{"family":"Mourcin","role":"aut","given":"Frédéric","display":"Mourcin, Frédéric"},{"family":"Vos","display":"Vos, John De","role":"aut","given":"John De"},{"family":"Kassambara","display":"Kassambara, Alboukadel","role":"aut","given":"Alboukadel"},{"display":"Duperray, Christophe","role":"aut","given":"Christophe","family":"Duperray"},{"family":"Hose","role":"aut","given":"Dirk","display":"Hose, Dirk"},{"family":"Fest","display":"Fest, Thierry","given":"Thierry","role":"aut"},{"family":"Tarte","display":"Tarte, Karin","role":"aut","given":"Karin"},{"given":"Bernard","role":"aut","display":"Klein, Bernard","family":"Klein"}],"name":{"displayForm":["Michel Jourdan, Anouk Caraux, Gersende Caron, Nicolas Robert, Geneviève Fiol, Thierry Rème, Karine Bolloré, Jean-Pierre Vendrell, Simon Le Gallou, Frédéric Mourcin, John De Vos, Alboukadel Kassambara, Christophe Duperray, Dirk Hose, Thierry Fest, Karin Tarte, and Bernard Klein"]},"physDesc":[{"extent":"11 S."}],"id":{"eki":["1809160626"],"doi":["10.4049/jimmunol.1101230"]},"note":["Gesehen am 05.07.2022"],"relHost":[{"note":["Gesehen am 18.08.2025"],"corporate":[{"role":"isb","display":"American Association of Immunologists"}],"disp":"Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiationThe journal of immunology","physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1550-6606"],"zdb":["1475085-5"],"eki":["269535217"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"269535217","origin":[{"publisherPlace":"Oxford ; Bethesda, Md. ; Rockville, Md.","dateIssuedKey":"2025","dateIssuedDisp":"2025-","publisher":"Oxford University Press ; Soc. ; American Association of Immunologists"}],"name":{"displayForm":["American Association of Immunologists"]},"pubHistory":["1.1916 -"],"part":{"issue":"8","pages":"3931-3941","extent":"11","year":"2011","text":"187(2011), 8, Seite 3931-3941","volume":"187"},"language":["eng"],"title":[{"title":"The journal of immunology","title_sort":"journal of immunology"}]}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1809160626","origin":[{"dateIssuedDisp":"October 3, 2011","dateIssuedKey":"2011"}],"title":[{"title_sort":"Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation","title":"Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation"}],"language":["eng"]} | ||
| SRT | |a JOURDANMICCHARACTERI3201 | ||