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Dose escalation to hypoxic subvolumes in head and neck cancer: a randomized phase II study using dynamic (18F)FMISO PET/CT

Background and purpose - Tumor hypoxia is a major cause of resistance to radiochemotherapy in locally advanced head-and-neck cancer (LASCCHN). We present results of a randomized phase II trial on hypoxia dose escalation (DE) in LASCCHN based on dynamic [18F]FMISO (dynFMISO) positron emission tomogra...

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Main Authors: Welz, Stefan (Author) , Paulsen, Frank (Author) , Pfannenberg, Christina (Author) , Reimold, Matthias (Author) , Reischl, Gerald (Author) , Nikolaou, Konstantin (Author) , La Fougère, Christian (Author) , Alber, Markus (Author) , Belka, Claus (Author) , Zips, Daniel (Author) , Thorwarth, Daniela (Author)
Format: Article (Journal)
Language:English
Published: June 2022
In: Radiotherapy and oncology
Year: 2022, Volume: 171, Pages: 30-36
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.03.021
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2022.03.021
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814022001700
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Author Notes:Stefan Welz, Frank Paulsen, Christina Pfannenberg, Matthias Reimold, Gerald Reischl, Konstantin Nikolaou, Christian La Fougère, Markus Alber, Claus Belka, Daniel Zips, Daniela Thorwarth
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Summary:Background and purpose - Tumor hypoxia is a major cause of resistance to radiochemotherapy in locally advanced head-and-neck cancer (LASCCHN). We present results of a randomized phase II trial on hypoxia dose escalation (DE) in LASCCHN based on dynamic [18F]FMISO (dynFMISO) positron emission tomography (PET). The purpose was to confirm the prognostic value of hypoxia PET and assess feasibility, toxicity and efficacy of hypoxia-DE. - Materials and methods - Patients with LASCCHN underwent baseline dynFMISO PET/CT. Hypoxic volumes (HV) were derived from dynFMISO data. Patients with hypoxic tumors (HV > 0) were randomized into standard radiotherapy (ST: 70Gy/35fx) or dose escalation (DE: 77Gy/35fx) to the HV. Patients with non-hypoxic tumors were treated with ST. After a minimum follow-up of 2 years feasibility, acute/late toxicity and local control (LC) were analyzed. - Results - The study was closed prematurely due to slow accrual. Between 2009 and 2017, 53 patients were enrolled, 39 (74%) had hypoxic tumors and were randomized into ST or DE. For non-hypoxic patients, 100% 5-year LC was observed compared to 74% in patients with hypoxic tumors (p = 0.039). The difference in 5-year LC between DE (16/19) and ST (10/17) was 25%, p = 0.150. No relevant differences related to acute and late toxicities between the groups were observed. - Conclusion - This study confirmed the prognostic value of hypoxia PET in LASCCHN for LC. Outcome after hypoxia DE appears promising and may support the concept of DE. Slow accrual and premature closure may partly be due to a high complexity of the study setup which needs to be considered for future multicenter trials.
Item Description:Available online 5 April 2022
Die Zahl "18" bei (18F) ist hochgestellt
Gesehen am 07.07.2022
Physical Description:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.03.021

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