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5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1

MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby extending the phenotypic impact of the respective common pre-m...

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Main Authors: Li, Xiaoya (Author) , Michels, Birgitta Elisabeth (Author) , Tosun, Oyku Ece (Author) , Jung, Janine (Author) , Kappes, Jolane (Author) , Ibing, Susanne (Author) , Nataraj, Nishanth Belugali (Author) , Sahay, Shashwat (Author) , Schneider, Martin (Author) , Wörner, Angelika (Author) , Becki, Corinna (Author) , Ishaque, Naveed (Author) , Feuerbach, Lars (Author) , Heßling, Bernd (Author) , Helm, Dominic (Author) , Will, Rainer (Author) , Yarden, Yosef (Author) , Müller-Decker, Karin (Author) , Wiemann, Stefan (Author) , Körner, Cindy (Author)
Format: Article (Journal)
Language:English
Published: 02 June 2022
In: Journal of experimental & clinical cancer research
Year: 2022, Volume: 41, Pages: 1-22
ISSN:1756-9966
DOI:10.1186/s13046-022-02380-8
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13046-022-02380-8
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Author Notes:Xiaoya Li, Birgitta Elisabeth Michels, Oyku Ece Tosun, Janine Jung, Jolane Kappes, Susanne Ibing, Nishanth Belugali Nataraj, Shashwat Sahay, Martin Schneider, Angelika Wörner, Corinna Becki, Naveed Ishaque, Lars Feuerbach, Bernd Heßling, Dominic Helm, Rainer Will, Yosef Yarden, Karin Müller-Decker, Stefan Wiemann and Cindy Körner
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Summary:MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby extending the phenotypic impact of the respective common pre-miRNA. However, for most miRNAs, expression and function of 5’isomiRs have not been studied in detail yet. Therefore, this study aims to investigate the functions of miRNAs and their 5’isomiRs.
Item Description:Gesehen am 07.07.2022
Physical Description:Online Resource
ISSN:1756-9966
DOI:10.1186/s13046-022-02380-8

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